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수록범위 : 1권1호(1992)~11권0호(2008) |수록논문 수 : 176
동국한의학연구소 논문집
11권0호(2008년 08월) 수록논문
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1일본 '고증파(考證派)' 의학에 관한 연구

저자 : 朴炫局 ( Park Hyun-kuk ) , 金基郁 ( Kim Ki-wook )

발행기관 : 동국대학교 한의학연구소 간행물 : 동국한의학연구소 논문집 11권 0호 발행 연도 : 2008 페이지 : pp. 1-40 (40 pages)

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1.The 'Kao Zheng Pai'(考證派) comes from the 'Zhe Zhong Pai(折衷派)' and is a school that is influenced by the confucianism of the Qing dynasty. In Japan Inoue Kinga(井上金峨 いのうえきん が), Yoshida Koton(古田篁墩 よしだこうとん 1745~1798) became central members, and the rise of the methodology of historical research(考證學) influenced the members of the 'Zhe Zhong Pai', and the trend of historical research changed from confucianism to medicine, making a school of medicine based on the study of texts and proving that the classics were right.
2. Based on the function of 'Nei Qu Li'(內驅力) the 'Kao Zheng Pai', in the spirit of 'use confucianism as the base', researched letters, meanings and historical origins. Because they were influenced by the methodology of historical research(考證學) of the Qing era, they valued the evidential research of classic texts, and there was even one branch that did only historical research, the 'Rue Xue Kao Zheng Pai'(儒學考證派). Also, the 'Yi Xue Kao Zheng Pai'(醫學考證派) appeared by the influence of Yoshida Kouton and Kariya Ekisai(狩谷掖齋 かりやえきさい).
3. In the 'Kao Zheng Pai(考證派)'s theories and views the 'Yi Xue Kao Zheng Pai' did not look at medical scriptures like the "Huang Di Nei Jing"("黃帝內經") and did not do research on 'medical' related areas like acupuncture, the meridian and medicinal herbs. Since they were doctors that used medicine, they naturally were based on 'formulas'(方劑) and since their thoughts were based on the historical ideologies, they valued the "Shang Han Ja Bing Lun" which was revered as the 'ancestor of all formulas'(衆方之祖).
4. The lives of the important doctors of the 'Kao Zheng Pai' Meguro Dotaku(目黑道琢) Yamada Seichin(山田正珍), Yamada Kyoko(山田業廣), Mori Ritsi(森立之) Kitamura Naohara(喜多村直寬) are as follows.
1) Meguro Dotaku(目黑道琢 めぐろどたく1739~1798) was born of lowly descent but, using his intelligence and knowledge, became a professor as a Shi Jing Yi(市井醫) and as a professor for 34 years at Ji Shou Guan(蹟壽館) mastered the "Huang Di Nei Jing" after giving over 300 lectures. Since his pupil, Isawara Ken(伊澤蘭軒 いさゎらんけん) taught the Lan Men Wu Zhe(蘭門五哲) and Shibue Chusai(澀江抽齋 しぶぇちゅぅさぃ), Mori Ritsi(森立之 もりりっし), Okanishi Gentei(岡西玄亭 おかにしげんてぃ), Kiyokawa Gendoh(淸川玄道 きょかゎげんどぅ) and Yamada Kyoko(山田業廣 ゃまだぎょぅこぅ), Meguro Dotaku is considered the founder of the 'Yi Xue Kao Zheng Pai'.
2) The family of Yamada Seichin(山田正珍 ゃまげ せぃちん 1749~1787) had been medical officials in the Makufu(幕府) and the many books that his ancestors had left were the base of his art. Seichin learned from Shan Ben Bei Shan(山本北山), a 'Zhe Zhong Pai' scholar, and put his efforts into learning, teaching and researching the "Shang Han Lun"("傷寒論"). Living in a time between 'Gu Fang Pai'(古方派) member Nakanishi Goretada(中西惟忠 なかにしこれただ) and 'Kao Zheng Pai' member Taki Motohiro(多紀元簡 たき もとひろ), he wrote 11 books, 2 of which express his thoughts and research clearly, the "Shang Han Lun Ji Cheng"("傷寒論集成") and "Shang Han Kao"("傷寒考"). His comparison of the 'six meridians'(3 yin, 3 yang) between the "Shang Han Lun" and the "Su Wen Re Lun"("素問熱論") and his acknowledgement of the need and rationality of the concept of Yin-Yang and Deficient-Replete distinguishes him from the other 'Gu Fang Pai'. Also, his dissertation of the need for the concept doesn't use the theories of latter schools but uses the theory of the "Shang Han Lun" itself. He even researched the historical parts, such as terms like 'Shen Nong Chang Bai Cao'(神農嘗百草) and 'Cheng Qi Tang'(承氣湯).
3) The ancestor of Yamada Kyoko(山田業廣 ゃまだぎょぅこぅ) was a court physician, and learned confucianism from Kao Zheng Pai's Ashikawa Genan(朝川善庵 ぁさかゎぜんぁん) and medicine from Isawa Ranken(伊澤蘭軒 ぃさゎらんけん) and Taki Motokata(多紀元堅 たきもとかた), and the secret to smallpox from Ikeda Keisui(池田京水 ぃけだけぃすぃ). He later became a lecturer at the Edo Yi Xue Guan(醫學館〉and was invited as the director to the Ji Zhong(濟衆)hospital. He also became the first owner of the Wen Zhi She(溫知社), whose main purpose was the revival of kampo, and launched the monthly magazine Wen Zi Yi Tan(溫知醫談). He also diagnosed and prescribed for the prince Ming Gong(明宮)
His works include the 『Jing Fang Bian』(『經方辨』), 『Shang Han Lun Si C』 (『傷寒論釋詞』), 『Huang Zhao Zhu Jia Zhi Yan Ji Yao』(『皇朝諸家治驗集要』)and 『Shang Han Ja Bing Lun Lei Juan』 (『傷寒雜病論類籍』). of these, the 『Jing Fang Bian』(『經方辨』) states that the Shi Gao(石膏)used in the 『Shang Han Lun』 had three meanings-Fa Biao(發表), Qing Re(淸熱), Zi Yin(滋陰)-which were from 'symptoms', and first deducted the effects and then told of the reason. Another book, the 『Jiu Zhe Tang Du Shu Ji』 (『九折堂讀書記』) researched and translated the difficult parts of the 『Shang Han Lun』, 『Jin Qui Yao Lue』(『金匱要略』), 『Qian Jin Fangj(『千金方』), and 『Wai Tai Mi Yao』(『外臺秘要』). He usually analyzed the 'symptoms' of diseases but the composition, measurement, processing and application of medicine were all in the spectrum of 'analystic research' and 'researching analysis'.
4)The ancestors of Mori Ritsi(森立之 もりりっし 1807 ~1885) were warriors but he became a doctor by the will of his mother, and he learned from Shibue Chosai(澁江抽齋 しぶぇ ちゅぅさぃ) and Isawaran Ken(伊澤蘭軒 ぃさゎらんけん) and later became a pupil of Shou Gu Yi Zhai(狩谷被齋), a historical research scholar. He then became a lecturer of medical herbs at the Yi Xue Guan, and later participated in the proofreading of 『Yi Xin Fang』(『醫心方』) and with Chosai compiled the 『Jing Ji Fang Gu Zhi』 『經籍訪占志』). He visited the Chinese scholar Yang Shou Jing(楊守敬)in 1881 and exchanged books and ideas. Of his works, there are the collections(輯複本)of 『Shen Nong Ben Cao Jing』(『神農本草經』) and 『You Xiang Yi hwa』(『遊相醫話』) and the records, notes, poems, and diaries such as 『Zhi Yuan Man Lu』『積園漫錄』) and 『Zhi Yuan Sui Bi』(『積園隨筆』) that were not published.
His thoughts were that in restoring the 『Shen Nong Ben Cao Jing』, “the herb to the doctor is like the 『Shuo Wen Jie Zi』 (『說文解字』) to the scholar”, and he tried to restore the ancient herbal text using knowledge of medicine and investigation(考據). Also with Chosai he compiled the 『Jing Ji Fang Gu Zhi』(『經籍訪古志』) using knowledge of ancient text.
Ritzi left works on pure investigation, paid much attention to social problems, and through 12 years of poverty treated all people and animals in all branches of medicine, so he is called a 'half confucianist half doctor'(半儒半醫).
5)Kitamurana Ohira(喜多村直寬 きたむらぢひら 1804~1876) learned scriptures and ancient texts from confucian scholar Asaka Gonsai(安積艮齋 あさかこんさぃ), and learned medicine from his father Huai Yaun(槐圓). He became a teacher in the Yi Xue Guan in his middle ages, and to repay his country, he printed 266 volumes of 『Yi Fang Lei Ju』 (『醫方類聚』) and 1000 volumes of 『Tai Ping Yu Lan』 (『太平製覽』) and devoted it to his country to be spread. His works are about 40 volumes including 『Jin Qui Yao Lue Shu Yi』 (『金匱要略疏義』) and 『Lao Yi Zhi Yan』 (『老醫巵言』) but most of them are researches on the 『Shang Han Za Bing Lun』. In his 『Shang Han Lun Shu Yi』 (『傷寒論疏義』)he shows the concept of the six meridians through the Yin-Yang, Superficial or internal, cold or hot, deficient or replete state of diseases, but did not match the names with the six meridians of the meridian theory, and this has something in common with the research based on the Confucianism of Song(宋儒). In clinical treatment he was positive toward old and new methods and also the experience of civilians, but was negative toward western medicine.
6) The ancestor of the Taki family Tanbano Yasuyori(丹波康賴 たんばのゃょり 1912 ~ 955) became a Yi Bo Shi(醫博士)by his medical skills and compiled the 『Yi Xin Fang』(『醫心方』). His first son Tanbano Shigeaki(丹波重明 たんばのしげあき) inherited the Shi Yao Yuan(施藥院) and the third son Tanbano Masatada(丹波雅忠 たんばのまさただ) inherited the Dian You Tou(典麴頭). Masatada's descendents succeeded him for 25 generations until the family name was changed to Jin Bao(金保) and five generations later it was changed again to Duo Ji(多紀). The research scholar Taki Motohiro was in the third generation alter the last name was changed to Taki, and his family kept an important part in the line of medical officers in Japan.
Taki Motohiro(多紀元簡 たき もとひろ 1755-1810) was a teacher in the Yi Xae Guan where his father was residing, and became the physician for the general Jia Qi(家齊). He had a short temper and was not good at getting on in the world, and went against the will of the king and was banished from Ao Yi Shi(奧醫師). His most famous works, the 『Shang Han Lun Ji Yi』 (『傷寒論輯義』) and 『Jin Qui Yao Lue Ji Yi』 (『金匱要略輯義』) are the work of 20 years of collecting the theories of many schools and discussing, and is one of the most famous books on the 『Shang Han Lun』 m Japan. 『Yi Sheng』 (『醫勝』) is a collection of essays on research. Also there are the 『Su Wen Shi』 (『素問識』), 『Liag Shu Shi』 (『靈樞識』), and the 『Guan Ju Fang Yao Bu』 (『觀聚方要補』)
Taki Motohiro(多紀元簡 たき もとひろ)'s position was succeeded by his third son Yuan Yin(元胤 1789~1827), and his works include works of research such as 『Nan Jing Shu Jeng』 (『難經疏證』), 『Ti Ya』 (『體雅』), 『Yao Ya』 (『藥雅』), 『Ji Ya』 (『疾雅』 『Ming Yi Gong An』 (『名醫公案』), and 『Yi Ji Kao』 (『醫籍考』). The 『Yi Ji Kao』 is 80 volumes in length and lists about 3000 books on medicine in China before the Qing Dao Guang(道光), and under each title are the origin, number of volumes, state of existence, and, if possible, the preface, Ba Yu(跋語)and biography of the author.
The younger sibling of Yuan Yin(元亂 1789-1827), Yuan Jian(元堅 1795~1857) expounded ancient writings at the Yi Xue Guan only after he reached middle age, was chosen for the Ao Yi Shi(奭緣師)and later became a Fa Yan(法眼), Fa Yin(法印) and Yu Chi(禦匙). He left about 15 texts, including『Su Wen Shao Shi』(『素問紹識』), 『Yi Xin Fang』『醫心方』), published in school, 『Za Bing Guang Yao』 (『雜病廣要』), 『Shang Han Guang Yao』 (『傷寒廣要』), and 『Zhen Fu Yao Jue』 (『診腹要訣』).
On the Taki family's founding and working of the Yi Xue Guan Yasuka Doumei(矢數道明 ゃかずどぅめぃ) said they were “the people who took the initiative in Edo era kampo medicine” and evaluated their deeds In the fields of 'research of ancient text', 'the founding of Ji Shou Guan(蹟壽館)and medical education', 'publication business', 'writing of medical text'.
5. The doctors of the 'Kao Zheng Pai' based their operations on the Edo Yi Xue Guan, and made groups with people with similar ideas to them, making a relationship 'net'. For example the three families of Duo Ji(多紀), Tang Chuan(湯川)and Xi Duo Cun(喜多村)married and adopted with and from each other and made prefaces and epitaphs for each other Thus, the Taki family, the state science of the Makufu, the tendency of thinking, one's own interests and glory, one's own knowledge, the need of the society all played a role in the development of kampo medicine in the 18th and 19th century.

2서양의 식이보충제와 기능성 식품에 대한 인식

저자 : 서민준 ( Min-jun Seo ) , 박진한 ( Jin-han Park )

발행기관 : 동국대학교 한의학연구소 간행물 : 동국한의학연구소 논문집 11권 0호 발행 연도 : 2008 페이지 : pp. 41-51 (11 pages)

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Dietary supplements are used by more than one-half of the adult US population. By contrast, herbal products in Germany are carefully regulated by the same standards as drugs, and efforts are under way to standardize their regulation in the entire European Union. Most herbal users do not inform their physicians that they are taking these supplements, and most physicians do not inquire. Although some herbal products have clinically proven benefits, it is increasingly apparent that many contain potentially toxic substances, particularly in relation to interactions with drugs. Hence, it is essential that practicing physicians develop a working knowledge of herbals-specifically, about claims for their usage and potential or proven efficacies and toxicities-and that they incorporate such knowledge into the evaluation and management of their patients. By contrast, functional foods-integral components of the diet that are understood to contribute added health benefits-are the subject of intense and widespread research in food and nutritional science. Examples include many polyphenolic substances, carotenoids, soy isoflavones, fish oils, and components of nuts that possess antioxidant and other properties that decrease the risk of vascular diseases and cancer. Practicing physicians are advised to stay abreast of these emerging findings in order to best advise their patients on the value of health-promoting diets in disease prevention.

3속수자 추출물의 HT-29 대장암세포 증식에 대한 억제효과

저자 : 정효원 ( Hyo Won Jung ) , 박용기 ( Yong-ki Park )

발행기관 : 동국대학교 한의학연구소 간행물 : 동국한의학연구소 논문집 11권 0호 발행 연도 : 2008 페이지 : pp. 52-60 (9 pages)

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Objectives. In this study, we investigate that methanol extract of Euphorbiae lathyridis Semen contributes to growth inhibitory effect on the HT-29 human colon cancer cells.
Methods. Euphorbiae lathyridis Semen (ELS) was extracted with 80% methanol. HT-29 cells were treated with different concentrations of ELS extract for 24-72 hrs. Growth inhibitory effect was determined by MTT assay. Cell apoptosis was determined by surveying caspases cascades activation using Western blot. Cell cycle arrest was analyzed by flow cytometry with PI staining.
Results. Exposure to ELS extract showed in inhibitory effects on HT-29 cell growth as a dose-dependent manner. Cell growth inhibition by ELS extract was related with induction of cell apoptosis with DNA fragmentation through the activation of caspases-3, caspase-9 and PARP cleavage.
Conclusion. ELS extract significantly inhibited cell growth and induced cell apoptosis in HT-29 human colon cancer cells, therefore, These results suggest that ELS extract can be used as chemoprevention agent of colon cancers.

4BHT-C의 허혈성 뇌졸중 동물에서의 뇌부종 억제효과

저자 : 김성윤 ( Sung Yoon Kim ) , 박용기 ( Yong Ki Park )

발행기관 : 동국대학교 한의학연구소 간행물 : 동국한의학연구소 논문집 11권 0호 발행 연도 : 2008 페이지 : pp. 58-65 (8 pages)

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Objectives : BHT has been commonly used to treatment of brain disorders in Oriental clinic in Korea. The purpose of this study was to determine the inhibitory effect of modified BHT-C extract on the transient forcal cerebral ischemia in rats.
Method : We prepared ischemic rats by the transient middle cerebral artery occlution(MCAO; 90 min occlusion and 144 h reperfusion) in rat brains. BHT-C extract (100 and 200 mg/kg, i.p.) was administered every day after the onset of MCAO until 6 day.
Result : BHT-C extract increased survival rate of ischemic rats compared with vehicle-treated rats. BHT-C extract treated rats (100 and 200 mg/kg) were shown a significant reduction in infarct volume compared with vehicle-treated rats.
Conclusions : These results suggest that BHT-C extract may contribute to its protective effects in brain ischemia through the reduction of brain infarction.

5mBHT의 랫드를 이용한 단회경구투여 독성시험

저자 : 박영철 ( Young Chul Park ) , 박용기 ( Yong-ki Park )

발행기관 : 동국대학교 한의학연구소 간행물 : 동국한의학연구소 논문집 11권 0호 발행 연도 : 2008 페이지 : pp. 66-73 (8 pages)

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Objectives: The study was designed to evaluate the single dose toxicity of modified Bo-yang-Hwan-o-Tang (mBHT) in Sprague-Dawley (SD) rats.
Methods: The mBHT was once administrated orally to both sexes of rats at dose 2,000 mg/kg body weight which are the recommended maximum limit dose for acute toxicity. We recorded clinical signs of toxicity, body weight, gross and histological changes in target organs for all rats.
Results: Neither significant changes of body weight not death was observed during the observation period in mBHT-administrated rats. Neither significant toxic signs not histopathological changes were shown during the observation period. There were not observed significant gross abnormality between the control and mBHT-administrated rats.
Conclusions: These results indicated that the toxicity of mBHT is greater than 2,000 mg/kg body weight in SD rats.

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