간행물

Journal of Gynecologic Oncology (JGO) update

  • : 대한부인종양학회(구 대한부인종양·콜포스코피학회)
  • : 의약학분야  >  산부인과학
  • : KCI등재
  • : SCI,SCOPUS
  • : 연속간행물
  • : 격월
  • : 2005-0380
  • :
  • : 대한부인종양.콜포스코피학회잡지(~2004)→부인종양(2005~)→Journal of Gynecologic Oncolgy (JGO)(2008~)

수록정보
수록범위 : 1권1호(1990)~29권6호(2018) |수록논문 수 : 1,415
Journal of Gynecologic Oncology (JGO)
29권6호(2018년 11월) 수록논문
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KCI등재 SCI SCOPUS

1Impact of beta blockers on survival outcomes in ovarian cancer: a nationwide population-based cohort study

저자 : Min-hyun Baek , Dae-yeon Kim , Seon Ok Kim , Ye-jee Kim , Young-han Park

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 1-13 (13 pages)

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Objective: The impact of beta blockers (BBs) on survival outcomes in ovarian cancer was investigated.
Methods: By using Korean National Health Insurance Service Data, Cox proportional hazards regression was performed to analyze hazard ratios (HRs) with 95% confidence intervals (CIs) adjusting for confounding factors.
Results: Among 866 eligible patients, 206 (23.8%) were BB users and 660 (76.2%) were non-users. Among the 206 BB users, 151 (73.3%) were non-selective beta blocker (NSBB) users and 105 (51.0%) were selective beta blocker (SBB) users. BB use in patients aged ≥60 years, longer duration use (≥1 year), in patients with Charlson Comorbidity Index (CCI) ≥3, and in cardiovascular disease including hypertension was associated with better survival outcome. These findings were observed in both NSBB and SBB. When duration of medication was analyzed based on number of days, NSBB (≥180 days) was associated with improved overall survival (OS) with a relatively shorter period of use compared to SBB (≥720 days). In multivariate Cox proportional hazards model, longer duration of BB medication (≥1 year) was an independent favorable prognostic factor for both OS and disease-specific survival in ovarian cancer patients.
Conclusion: In our nationwide population-based cohort study, BB use was associated with better survival outcomes in ovarian cancer in cases of long term duration of use, in older patients, and in cardiovascular and/or other underlying disease (CCI ≥3).

KCI등재 SCI SCOPUS

2Quality indicators for cervical cancer care in Japan

저자 : Tomone Watanabe , Mikio Mikami , Hidetaka Katabuchi , Shingo Kato , Masanori Kaneuchi , Masahiro Takahashi , Hidekatsu Nakai , Satoru Nagase , Hitoshi Niikura , Masaki Mandai , Yasuyuki Hirashima , Hiroyuki Yan

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 14-23 (10 pages)

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Objective: We aimed to propose a set of quality indicators (QIs) based on the clinical guidelines for cervical cancer treatment published by The Japan Society of Gynecologic Oncology, and to assess adherence to standard-of-care as an index of the quality of care for cervical cancer in Japan.
Methods: A panel of clinical experts devised the QIs using a modified Delphi method. Adherence to each QI was evaluated using data from a hospital-based cancer registry of patients diagnosed in 2013, and linked with insurance claims data, between October 1, 2012, and December 31, 2014. All patients who received first-line treatment at the participating facility were included. The QI scores were communicated to participating hospitals, and additional data about the reasons for non-adherence were collected.
Results: In total, 297 hospitals participated, and the care provided to 15,163 cervical cancer patients was examined using 10 measurable QIs. The adherence rate ranged from 50.0% for 'cystoscope or proctoscope for stage IVA' to 98.8% for 'chemotherapy using platinum for stage IVB'. Despite the variation in care, hospitals reported clinically valid reasons for more than half of the non-adherent cases. Clinically valid reasons accounted for 75%, 90.9%, 73.4%, 44.5%, and 88.1% of presented non-adherent cases respectively.
Conclusion: Our study revealed variations in pattern of care as well as an adherence to standards-of-care across Japan. Further assessment of the causes of variation and non-adherence can help identify areas where improvements are needed in patient care.

KCI등재 SCI SCOPUS

3Trachelectomy for stage IB1 cervical cancer with tumor size >2 cm: trends and characteristics in the United States

저자 : Koji Matsuo , Hiroko Machida , Rachel S. Mandelbaum , Mikio Mikami , Takayuki Enomoto , Lynda D. Roman , Jason D. Wright

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 24-28 (5 pages)

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KCI등재 SCI SCOPUS

4Robotic lower pelvic port placement for optimal upper paraaortic lymph node dissection

저자 : Jiheum Paek , Elizabeth Kang , Peter C. Lim

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 29-32 (4 pages)

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Objective: Upper paraaortic lymph node dissection (UPALD) to the infrarenal level is one of the most challenging robotic procedures. Because robotic system has the limitation in robotic arm mobility. This surgical video introduces a novel robotic approach, lower pelvic port placement (LP3), to perform optimally and simultaneously both UPALD and pelvic procedures in gynecologic cancer patients using da Vinci Xi system.
Methods: The patient presented with high-grade endometrial cancer. She underwent robotic surgical staging operation. For the setup of the LP3, a line was drown between both anterior superior iliac spines. At 3 cm below this line, another line was drown and four robotic ports were placed on this line.
Results: After paraaortic lymph node dissection (PALD) was completed, the boom of robotic system was rotated 180° to retarget for the pelvic lateral displacement. Robotic ports were placed and docked again. The operation was completed robotically without any complication.
Conclusion: The LP3 was feasible for performing simultaneously optimal PALD as well as procedures in pelvic cavity in gynecologic cancer patients. The advantage of LP3 technique is the robotic port placement that affords for multi-quadrant surgery, abdominal and pelvic dissection. The LP3 is facilitated by utilizing advanced technology of Xi system, including the patient clearance function, the rotating boom, and 'port hopping' that allows using every ports for a camera. The LP3 will enable surgeons to extend the surgical indication of robotic surgical system in the gynecologic oncologic field.

KCI등재 SCI SCOPUS

5Clinical utility of CA-125 in the management of uterine carcinosarcoma

저자 : Koji Matsuo , Malcolm S. Ross , Mayu Yunokawa , Marian S. Johnson , Hiroko Machida , Kohei Omatsu , Merieme M. Klobocista , Dwight D. Im , Shinya Satoh , Tsukasa Baba , Yuji Ikeda , Stephen H. Bush , Kosei

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 33-39 (7 pages)

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KCI등재 SCI SCOPUS

6Treatment results of the second-line chemotherapy regimen for patients with low-risk gestational trophoblastic neoplasia treated with 5-day methotrexate and 5-day etoposide

저자 : Toshiyuki Kanno , Hideo Matsui , Yoshika Akizawa , Hirokazu Usui , Makio Shozu

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 40-47 (8 pages)

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Objective: Highly effective chemotherapy for patients with low-risk gestational trophoblastic neoplasia (GTN) is associated with almost a 100% cure rate. However, 20%-30% of patients treated with chemotherapy need to change their regimens due to severe adverse events (SAEs) or drug resistance. We examined the treatment outcomes of second-line chemotherapy for patients with low-risk GTN.
Methods: Between 1980 and 2015, 281 patients with low-risk GTN were treated. Of these 281 patients, 178 patients were primarily treated with 5-day intramuscular methotrexate (MTX; n=114) or 5-day drip infusion etoposide (ETP; n=64). We examined the remission rates, the drug change rates, and the outcomes of second-line chemotherapy.
Results: The primary remission rates and drug resistant rates of 5-day ETP were significantly higher (p<0.001) and significantly lower (p=0.002) than those of 5-day MTX, respectively. Forty-seven patients (26.4%) required a change in their chemotherapy regimen due to the SAEs (n=16) and drug resistance (n=31), respectively. Of these 47 patients failed the first-line regimen, 39 patients (39/47, 82.9%) were re-treated with single-agent chemotherapy, and 35 patients (35/39, 89.7%) achieved remission. Four patients failed second-line, single-agent chemotherapy and eight patients (17.0%) who failed first-line regimens were treated with combined or multi-agent chemotherapy and achieved remission.
Conclusions: Patients with low-risk GTN were usually treated with single-agent chemotherapy, while 20%-30% patients had to change their chemotherapy regimen due to SAEs or drug resistance. The second-line regimens of single-agent chemotherapy were effective; however, there were several patients who needed multiple agents and combined chemotherapy to achieve remission.

KCI등재 SCI SCOPUS

7BRCA1/2 mutations, including large genomic rearrangements, among unselected ovarian cancer patients in Korea

저자 : Do-hoon Kim , Chi-heum Cho , Sun Young Kwon , Nam-hee Ryoo , Dong-seok Jeon , Wonmok Lee , Jung-sook Ha

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 48-59 (12 pages)

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Objective: We performed small-scale mutation and large genomic rearrangement (LGR) analysis of BRCA1/2 in ovarian cancer patients to determine the prevalence and the characteristics of the mutations.
Methods: All ovarian cancer patients who visited a single institution between September 2015 and April 2017 were included. Sanger sequencing, multiplex ligation-dependent probe amplification (MLPA), and long-range polymerase chain reaction (PCR) were performed to comprehensively study BRCA1/2. The genetic risk models BRCAPRO, Myriad, and BOADICEA were used to evaluate the mutation analysis.
Results: In total, 131 patients were enrolled. Of the 131 patients, Sanger sequencing identified 16 different BRCA1/2 small-scale mutations in 20 patients (15.3%). Two novel nonsense mutations were detected in 2 patients with a serous borderline tumor and a large-cell neuroendocrine carcinoma. MLPA analysis of BRCA1/2 in Sanger-negative patients revealed 2 LGRs. The LGRs accounted for 14.3% of all identified BRCA1 mutations, and the prevalence of LGRs identified in this study was 1.8% in 111 Sanger-negative patients. The genetic risk models showed statistically significant differences between mutation carriers and non-carriers. The 2 patients with LGRs had at least one blood relative with breast or ovarian cancer.
Conclusion: Twenty-two (16.8%) of the unselected ovarian cancer patients had BRCA1/2 mutations that were detected through comprehensive BRCA1/2 genetic testing. Ovarian cancer patients with Sanger-negative results should be considered for LGR detection if they have one blood relative with breast or ovarian cancer. The detection of more BRCA1/2 mutations in patients is important for efforts to provide targeted therapy to ovarian cancer patients.

KCI등재 SCI SCOPUS

8Association of tumor differentiation grade and survival of women with squamous cell carcinoma of the uterine cervix

저자 : Koji Matsuo , Rachel S. Mandelbaum , Hiroko Machida , Sanjay Purushotham , Brendan H. Grubbs , Lynda D. Roman , Jason D. Wright

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 60-71 (12 pages)

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Objective: To examine the association between tumor grade and survival for women with squamous cervical cancer.
Methods: This retrospective observational study utilized the Surveillance, Epidemiology, and End Result program data between 1983 and 2013 to examine women with squamous cervical cancer with known tumor differentiation grade. Multivariable analyses were performed to assess independent associations between tumor differentiation grade and survival.
Results: A total of 31,536 women were identified including 15,175 (48.1%) with grade 3 tumors, 14,084 (44.7%) with grade 2 neoplasms and 2,277 (7.2%) with grade 1 tumors. Higher tumor grade was significantly associated with older age, higher stage disease, larger tumor size, and lymph node metastasis (all, p<0.001). In a multivariable analysis, grade 2 tumors (adjusted-hazard ratio [HR]=1.21; p<0.001) and grade 3 tumors (adjusted-HR=1.45; p<0.001) were independently associated with decreased cause-specific survival (CSS) compared to grade 1 tumors. Among the 7,429 women with stage II-III disease who received radiotherapy without surgical treatment, grade 3 tumors were independently associated with decreased CSS compared to grade 2 tumors (adjusted-HR=1.16; p<0.001). Among 4,045 women with node-negative stage I disease and tumor size ≤4 cm who underwent surgical treatment without radiotherapy, grade 2 tumors (adjusted-HR=2.54; p=0.028) and grade 3 tumors (adjusted-HR=4.48; p<0.001) were independently associated with decreased CSS compared to grade 1 tumors.
Conclusion: Our study suggests that tumor differentiation grade may be a prognostic factor in women with squamous cervical cancer, particularly in early-stage disease. Higher tumor grade was associated with poorer survival.

KCI등재 SCI SCOPUS

9Effect of the pulmonary recruitment maneuver on pain after laparoscopic gynecological oncologic surgery:a prospective randomized trial

저자 : Kemal Gungorduk , Osman Asicioglu , Isa Aykut Ozdemir

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 72-80 (9 pages)

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Objective: To evaluate the effectiveness of the pulmonary recruitment maneuver (PRM) at the end of the operation to decrease laparoscopy-induced abdominal or shoulder pain after gynecological oncologic surgery.
Methods: In total, 113 women undergoing laparoscopic surgery for malignant or premalignant gynecological lesions were assigned randomly to two groups: the PRM group (the patient was placed in the Trendelenburg position (30°) and the PRM, consisting of two manual pulmonary inflations to a maximum pressure of 40 cmH2O) (n=54) and the control group (n=52). Postoperative shoulder and abdominal pain was assessed 12, 24, and 48 hours later using a visual analog scale (0-10). In addition, the incidence of post-discharge nausea and vomiting was recorded until 48 hours after discharge.
Results: Postoperative shoulder pain at 12 and 24 hours was significantly less severe in the PRM group (2.2±0.5 and 2.0±0.4) than in the control group (4.0±0.5 and 3.9±0.4; both p<0.001). The PRM significantly reduced the severity of upper abdominal pain at 12 and 24 h compared with the control group (3.1±0.4 and 2.9±0.4 vs. 5.9±0.5 and 4.9±0.5; both p<0.001). The analgesic requirement during the postoperative period was similar in the two groups (control group, 78.8%; PRM group, 75.9%; p=0.719).
Conclusion: The PRM effectively and safely reduced postoperative shoulder and upper abdominal pain levels in patients undergoing laparoscopic gynecological oncologic surgery. Trial registry at ClinicalTrials.gov, NCT01940042.

KCI등재 SCI SCOPUS

10Checkpoint-inhibition in ovarian cancer: rising star or just a dream?

저자 : Klaus Pietzner , Sara Nasser , Sara Alavi , Silvia Darb-esfahani , Mona Passler , Mustafa Zelal Muallem , Jalid Sehouli

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 6호 발행 연도 : 2018 페이지 : pp. 81-91 (11 pages)

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The introduction of checkpoint inhibitors revolutionized immuno-oncology. The efficacy of traditional immunotherapeutics, like vaccines and immunostimulants was very limited due to persistent immune-escape strategies of cancer cells. Checkpoint inhibitors target these escape mechanisms and re-direct the immune system to anti-tumor toxicity. Phenomenal results have been reported in entities like melanoma, where no other therapy was able to demonstrate survival benefit, before the introduction of immunotherapeutics. The first experience in ovarian cancer (OC) was reported for nivolumab, a fully human anti-programmed cell death protein 1 (PD1) antibody, in 2015. While the data are extraordinary for a mono-immunotherapeutic agent and very promising, they do not match up to the revolutionary results in entities like melanoma. The key to exceptional treatment response in OC, could be the identification of the most immunogenic patients. We hypothyse that BRCA mutation could be a predictor of improved response in OC. The underlying DNA-repair-deficiancy should result in increased immunogenicity because of higher mutational load and more neoantigen presentation. This hypothesis was not tested to date and should be subject to future trials. The present article gives an overview of the immunologic background of checkpoint inhibition (CI). It presents current data on nivolumab and other checkpoint-inhibitors in solid tumors and OC specifically and depicts important topics in the management of this novel substance group, such as side effect control, diagnostic PD-1/programmed cell death-ligand 1 (PD-L1) expression assessment and management of pseudoprogression.

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