간행물

Journal of Gynecologic Oncology (JGO) update

  • : 대한부인종양학회(구 대한부인종양·콜포스코피학회)
  • : 의약학분야  >  산부인과학
  • : KCI등재
  • : SCI,SCOPUS
  • : 연속간행물
  • : 격월
  • : 2005-0380
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  • : 대한부인종양.콜포스코피학회잡지(~2004)→부인종양(2005~)→Journal of Gynecologic Oncolgy (JGO)(2008~)

수록정보
수록범위 : 1권1호(1990)~29권5호(2018) |수록논문 수 : 1,397
Journal of Gynecologic Oncology (JGO)
29권5호(2018년 09월) 수록논문
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KCI등재 SCI SCOPUS

1Prognostic impact of reduced tumor-free margin distance on long-term survival in FIGO stage IB/II vulvar squamous cell carcinoma

저자 : Leonardo Micheletti , Mario Preti , Viviana Cintolesi , Elisabetta Corvetto , Silvana Privitera , Eleonora Palmese , Chiara Benedetto

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-11 (11 pages)

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Objective: We aimed to identify the minimum tumor-free margin distance conferring long-term oncological safety in patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IB/II vulvar squamous cell carcinoma (VSCC).
Methods: This was a retrospective cohort study in patients with stage IB/II VSCC treated at a single institution in Turin, Italy. The main aim was to identify the minimum tumor-free margin distance that confers oncological safety in early-stage VSCC. Patients were divided in groups according to tumor-free histological margin distance to compare survival outcomes. Overall survival (OS), disease-specific survival (DSS), and recurrence rate (RR) were estimated by the Kaplan-Meier method for the newly proposed and the currently recommended 8 mm margin cut-off. Log-rank test was used to compare survival between groups.
Results: One hundred and fourteen patients met the study criteria. Median age was 68 years and median follow-up was 80 months. The minimum margin distance that conferred long-term oncological safety was 5 mm. OS, DSS were significantly lower in the <5 mm group when compared with the ≥5 mm group (p=0.002 and p=0.033, respectively) although no difference in RR was observed between groups. Analysis at the 8-mm cut-off indicated there is no difference in OS, DSS, or RR between groups.
Conclusion: FIGO stage IB/II VSCC patients' prognosis is affected by margin distance. Long-term survival is significantly reduced in patients with tumor-free margins <5 mm, even in the absence of lymph node metastasis. Thus, these patients should be offered further surgical or adjuvant treatment.

KCI등재 SCI SCOPUS

2Efficacy of palonosetron plus dexamethasone in preventing chemotherapy-induced nausea and emesis in patients receiving carboplatin-based chemotherapy for gynecologic cancers: a phase II study by the West Japan Gynecologic Oncology Group (WJGOG 131)

저자 : Shin Nishio , Satomi Aihara , Mototsugu Shimokawa , Akira Fujishita , Shuichi Taniguchi , Toru Hachisuga , Shintaro Yanazume , Hiroaki Kobayashi , Fumihiro Murakami , Fumitaka Numa , Kohei Kotera , Naofumi Okur

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-13 (13 pages)

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Objective: Palonosetron is effective for the management of acute and delayed chemotherapy-induced nausea and vomiting (CINV). While emetogenic carboplatin-based chemotherapy is widely used to treat gynecologic cancers, few studies have evaluated the antiemetic effectiveness of palonosetron in this setting.
Methods: A multicenter, single-arm, open-label phase II trial was conducted to evaluate the safety and effectiveness of palonosetron in controlling CINV in patients with gynecologic cancer. Chemotherapy-naïve patients received intravenous palonosetron (0.75 mg/body) and dexamethasone before the infusion of carboplatin-based chemotherapy on day 1. Dexamethasone was administered (orally or intravenously) on days 2-3. The incidence and severity of CINV were evaluated using the patient-completed Multinational Association of Supportive Care in Cancer Antiemesis Tool and treatment diaries. The primary endpoint was the proportion of patients experiencing complete control (CC) of vomiting, with “no rescue antiemetic medication” and “no clinically significant nausea” or “only mild nausea” in the delayed phase (24-120 hours post-chemotherapy). Secondary endpoints were the proportion of patients with a complete response (CR: “no vomiting” and “no rescue antiemetic medication”) in the acute (0-24 hours), delayed (24-120 hours), and overall (0-120 hours) phases, and CC in the acute and overall phases.
Results: Efficacy was assessable in 77 of 80 patients recruited. In the acute and delayed phases, the CR rates the primary endpoint, were 71.4% and 59.7% and the CC rates, the secondary endpoint, were 97.4% and 96.1%, respectively.
Conclusion: While palonosetron effectively controls acute CINV, additional antiemetic management is warranted in the delayed phase after carboplatin-based chemotherapy in gynecologic cancer patients (Trial registry at UMIN Clinical Trials Registry, UMIN000012806).

KCI등재 SCI SCOPUS

3Using low-coverage whole genome sequencing technique to analyze the chromosomal copy number alterations in the exfoliative cells of cervical cancer

저자 : Tong Ren , Jing Suo , Shikai Liu , Shu Wang , Shan Shu , Yang Xiang , Jing-he Lang

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-12 (12 pages)

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Objectives: We analyzed the chromosomal-arm-level copy number alterations (CNAs) in the cervical exfoliative cell and tissue samples by using the low-coverage whole genomic sequencing technique.
Methods: In this study, we retrospectively collected 55 archived exfoliated cervical cell suspension samples and the corresponding formalin-fixed and paraffin-embedded tissue section samples including 27 invasive cervical cancer and 28 control cases. We also collected 19 samples of the cervical exfoliative cells randomly from women to verify the new algorithm model. We analyzed the CNAs in cervical exfoliated cell and tissue samples by using the low-coverage next generation of sequencing.
Results: In the model-building study, multiple chromosomal-arm-level CNAs were detected in both cervical exfoliated cell and tissue samples of all cervical cancer cases. By analyzing the consistency of CNAs between exfoliated cells and cervical tissue samples, as well as the heterogeneity in individual patient, we also established a C-score algorithm model according to the chromosomal-arm-level changes of 1q, 2q, 3p, 7q. The C-score model was then validated by the pathological diagnosis of all 74 exfoliated cell samples (including 55 cases in model-building group and 19 cases in verification group). In our result, a cutoff value of C-score >6 showed 100% sensitivity and 100% specificity in the diagnosis of cervical cancer.
Conclusion: In this study, we found that CNAs of cervical exfoliated cell samples could robustly distinguish invasive cervical cancer from cancer-free tissues. And we have also developed a C-score algorithm model to process the sequencing data in a more standardized and automated way.

KCI등재 SCI SCOPUS

4Teenage pregnancy complicated by primary invasive ovarian cancer: association for oncologic outcome

저자 : Erin A. Blake , Madushka Y. De Zoysa , Elise B. Morocco , Samantha B. Kaiser , Michiko Kodama , Brendan H. Grubbs , Koji Matsuo

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-9 (9 pages)

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Objective: To examine survival of teenage women with pregnancies complicated by primary ovarian cancer.
Methods: This is a secondary analysis of a previously organized systematic literature review of primary ovarian cancer diagnosed during pregnancy. Cases eligible for analysis were patients whose age at cancer diagnosis and survival outcome were known (n=201). Pregnancy and oncologic outcome were then examined based on patient age.
Results: These were comprised of 95 (47.3%) epithelial ovarian cancers (EOCs), 82 (40.8%) malignant germ cell tumors (MGCTs), and 24 (11.9%) sex-cord stromal tumors (SCSTs). Teenage pregnancy was seen in 21 (10%) cases, and was highest among the SCST group compared to the other cancer types (EOC, 1.1%; MGCT, 14.6%; and SCST, 29.2%, p< 0.001). Live birth rates, neonatal weight, full term delivery rates, and Cesarean section rates were similar between the teenage group and the non-teenage group (all, p >0.05); however, teenage pregnancy was significantly associated with an increased risk of serious maternal/neonatal adverse events (50% vs. 22.7%, p=0.013). On univariable analysis, teenage pregnancy was significantly associated with decreased ovarian cancer-specific survival (5-year rate: age ≥30, 79.6%; age 20-29, 87.2%; and age <20, 41.6%; p<0.001). On multivariable analysis controlling for calendar year, cancer type, cancer stage, and gestational age at ovarian cancer diagnosis, teenage pregnancy remained an independent prognostic factor for decreased ovarian cancer-specific survival compared to women aged ≥30 (adjusted-hazard ratio=4.71; 95% confidence interval=1.17-18.9; p=0.029).
Conclusion: Teenage women with pregnancies complicated by primary ovarian cancer may be at increased risk of poor survival from ovarian cancer.

KCI등재 SCI SCOPUS

5Erratum: Prevalence of germline BRCA mutations among women with carcinoma of the peritoneum or fallopian tube

저자 : Min Chul Choi , Jin-sik Bae , Sang Geun Jung , Hyun Park , Won Duk Joo , Seung Hun Song , Chan Lee , Ji-ho Kim , Ki-chan Lee , Sunghoon Lee , Je Ho Lee

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-2 (2 pages)

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6A practical guide to understanding, using and including patient reported outcomes in clinical trials in ovarian cancer

저자 : Michelle K. Wilson , Rebecca Mercieca-bebber , Michael Friedlander

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-14 (14 pages)

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Health related quality of life (HRQOL) is a key priority for patients with ovarian cancer as there is significant morbidity associated with the disease and the treatment. It is therefore essential to include measures of HRQOL and patient reported outcomes (PROs) in all clinical trials and ideally report them in the initial manuscript. The results of these analyses help interpret the primary trial endpoints which are typically progression free survival and overall survival from the perspective of the patients, but can also assist with regulatory approval of new drugs and inform future patients regarding the potential benefits and downsides of the treatment as well as help support clinical recommendations. Including PROs in clinical trials allows patient-defined clinical benefits to be assessed in parallel to traditional survival outcomes to provide a more holistic overview and aid in the interpretation of the trial results. Given the importance of these instruments in clinical trials, greater effort is required to improve the appropriate inclusion, quality of analyses and reporting of PROs. It is also essential that all clinicians understand the intricacies of the selection, implementation and interpretation of these measures of HRQOL and PRO's and how important their contribution is to clinical trials as well as clinical practice. This review is a practical guide for clinicians to gain a better understanding of PROs and how they can be incorporated into ovarian cancer trials.

KCI등재 SCI SCOPUS

7Treatment outcomes of patients with stage II pure endometrioid-type endometrial cancer: a Taiwanese Gynecologic Oncology Group (TGOG-2006) retrospective cohort study

저자 : Hung-chun Fu , Jen-ruei Chen , Min-yu Chen , Keng-fu Hsu , Wen-fang Cheng , An-jen Chiang , Yu-min Ke , Yu-chieh Chen , Yin-yi Chang , Chia-yen Huang , Chieh-yi Kang , Yuan-yee Kan , Sheng-mou Hsiao , M

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-12 (12 pages)

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Objective: Choice of hysterectomy and adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid endometrial cancer (EEC) is still controversial. Aims of this study were to evaluate survival benefits and adverse effects of different hysterectomies with or without adjuvant radiotherapy (RT), and to identify prognostic factors.
Methods: The patients at 14 member hospitals of the Taiwanese Gynecologic Oncology Group from 1992 to 2013 were retrospectively investigated. Patients were divided into simple hysterectomy (SH) alone, SH with RT, radical hysterectomy (RH) alone, and RH with RT groups. Endpoints were recurrence-free survival (RFS), overall survival (OS), disease-specific survival (DSS), adverse effects and prognostic factors for survival.
Results: Total of 246 patients were enrolled. The 5-year RFS, OS, DSS and recurrence rates for the entire cohort were 89.5%, 94.3%, 96.2% and 10.2%, respectively. Patients receiving RH had more adverse effects including blood loss (p<0.001), recurrent urinary tract infections (p=0.013), and leg lymphedema (p=0.038). Age over 50-year (HR=9.2; 95% confidence interval [CI], 1.2-70.9) and grade 3 histology (HR=7.28; 95% CI, 1.45-36.6) were independent predictors of OS. Grade 3 histology was an independent predictor of RFS (HR=5.13; 95% CI, 1.38-19.1) and DSS (HR=5.97; 95% CI, 1.06-58.7). Patients receiving adjuvant RT had lower locoregional recurrence (p=0.046), but no impact on survival.
Conclusion: Different treatment modalities yield similar survival outcomes. Patients receiving SH with RT had lower locoregional recurrent with acceptable morbidity. Age and tumor grading remained significant predictors for survival among patients with FIGO 2009 stage II EEC.

KCI등재 SCI SCOPUS

8Lynch syndrome - Muir-Torre variant: implication in gynecologic oncology

저자 : Giorgio Bogani , Umberto Leone Roberti Maggiore , Francesco Raspagliesi

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-2 (2 pages)

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9The influence of hormone therapy with drospirenone-estradiol on endometrioid type endometrial cancer patients

저자 : Soyi Lim , Yun Hwan Kim , Kwang-beom Lee , Jong-min Lee

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-9 (9 pages)

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Objective: To determine whether drospirenone/estradiol (DRSP/E2) has an adverse effect on clinical outcomes in surgically staged International Federation of Gynecology and Obstetrics (FIGO) stage I/II endometrial cancer (EC) patients.
Methods: In a retrospective case-controlled study, 58 women with EC who had received DRSP/E2 postoperatively were compared with 116 women who had not. And, oncologic safety of postoperative hormone therapy with DRSP/E2 in EC survivors were compared between the 2 groups after propensity score matching using a logistic regression model.
Results: The median ages were 47.7 years and 53.6 years for the study and the control groups, respectively (p<0.001). The study group had similar parity (p=0.71), lower body mass index (p=0.03) and more premenopausal women (p<0.001) than the control group. The stages were completely matched. The grades (p=0.42), lymphovascular space invasion (p=0.23), preoperative cancer antigen 125 (CA 125) level (p=0.89), and hormone receptor status (p=0.07) were similar in both groups. The median tumor diameter was statistically larger in the study group than in the control group (p<0.001). Both group received similar adjuvant therapy (p=0.80). In the propensity matching, only hormone receptor status was significantly different (p=0.03). In the univariate analysis, only stage was significantly associated with disease-free survival (DFS) and there was no variable associated with overall survival (OS). And, there was no significant factor identified in multivariate analysis. The difference in the DFS (p=0.63) and in the OS (p=0.32) was not significant. The same results were obtained after propensity score matching.
Conclusion: Postoperative hormone therapy with DRSP/E2 in EC survivors did not increase recurrence or the death rate.

KCI등재 SCI SCOPUS

10Adequate pelvic lymphadenectomy and survival of women with early-stage epithelial ovarian cancer

저자 : Koji Matsuo , Hiroko Machida , Andrea Mariani , Rachel S. Mandelbaum , Gretchen E. Glaser , Bobbie S. Gostout , Lynda D. Roman , Jason D. Wright

발행기관 : 대한부인종양학회(구 대한부인종양·콜포스코피학회) 간행물 : Journal of Gynecologic Oncology (JGO) 29권 5호 발행 연도 : 2018 페이지 : pp. 1-15 (15 pages)

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Objective: To examine the trends and survival for women with early-stage epithelial ovarian cancer who underwent adequate lymphadenectomy during surgical treatment.
Methods: This is a retrospective observational study examining the Surveillance, Epidemiology, End Results program between 1988 and 2013. We evaluated 21,537 cases of stage I-II epithelial ovarian cancer including serous (n=7,466), clear cell (n=6,903), mucinous (n=4,066), and endometrioid (n=3,102) histology. A time-trend analysis of the proportion of patients who underwent adequate pelvic lymphadenectomy (≥8 per Gynecologic Oncology Group [GOG] criteria, ≥12 per Collaborative Group Report [CGR] criteria for bladder cancer, and >22 per Mayo criteria for endometrial cancer) and a survival analysis associated with adequate pelvic lymphadenectomy were performed.
Results: There were significant increases in the proportion of women who underwent adequate lymphadenectomy: GOG criteria 3.6% to 28.6% (1988-2010); CGR criteria 2.4% to 22.4% (1988-2013); and Mayo criteria 0.7% to 9.5% (1988-2013) (all, p<0.05). On multivariable analysis, adequate lymphadenectomy was independently associated with improved cause-specific survival compared to inadequate lymphadenectomy: GOG criteria, adjusted-hazard ratio (HR)=0.75, CGR criteria, adjusted-HR=0.77, and Mayo criteria, adjusted-HR=0.85 (all, p<0.05). Compared to inadequate lymphadenectomy, adequate lymphadenectomy was significantly associated with improved cause-specific survival for serous (HR range=0.67-0.73), endometrioid (HR range=0.59-0.61), and clear cell types (HR range=0.66-0.73) (all, p< 0.05) but not in mucinous type (HR range=0.80-0.91; p >0.05).
Conclusion: Quality of lymphadenectomy during the surgical treatment for early-stage epithelial ovarian cancer has significantly improved. Adequate lymphadenectomy is associated with a 15%-25% reduction in ovarian cancer mortality compared to inadequate lymphadenectomy.

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