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대한소화기학회> 대한소화기학회지

대한소화기학회지 update

The Korean Journal of Gastroenterology

  • : 대한소화기학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 월간
  • : 1598-9992
  • : 2233-6869
  • : 대한소화기병학회잡지(~1989)→대한소화기병학회지(1990~)→대한소화기학회지(1995~)

수록정보
수록범위 : 1권1호(1968)~73권3호(2019) |수록논문 수 : 5,445
대한소화기학회지
73권3호(2019년 03월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1조기 간암 완치를 위한 국소치료: 병합치료가 효과적인가?

저자 : 이세환 ( Sae Hwan Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 121-123 (3 pages)

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KCI등재 SCOPUS

2진행성 췌장 신경내분비 종양 치료의 최신 지견

저자 : 조창민 ( Chang Min Cho )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 124-131 (8 pages)

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Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms arising from the pancreatic islet of Langerhans and can be functioning or non-functioning based on the clinical symptoms caused by hormonal secretions. PNETs are the second most common tumor of the pancreas and represent 1-2% of all pancreatic neoplasms. The incidence of pNETs appears to be rising and the prognosis seems to be improving, likely due to the improved treatment options. Recent updates of the World Health Organization classification and grading separate pNETs into 2 broad categories according to the histopathologic criteria, including the Ki-67 proliferative index and mitotic counts: well-differentiated NET and poorly-differentiated neuroendocrine carcinoma (NEC). The classification also incorporates a new subcategory of well-differentiated high-grade NEC (grade 3) to the well-differentiated NET category. This new classification algorithm aims to improve the prediction of the clinical outcomes and survival and help clinicians select better therapeutic strategies for patient care and management. The treatment of advanced or metastatic pNETs may include surgical resection, liver- directed therapies, and/or systemic treatments. In unresectable patients, the goals of these therapies are to palliate the tumor-related symptoms and prolong the lifespan. Systemic therapy consists of the following broad modalities: somatostatin analogues, molecular targeted therapy, systemic chemotherapy, and peptide receptor radionuclide therapy. In conclusion, pNETs are diagnosed increasingly throughout the world, usually with metastatic disease and requiring systemic therapy. Each patient should be evaluated thoroughly and discussed individually by a multidisciplinary and dedicated NET-expert team, which might consider all treatment options, including ongoing clinical trials before selecting the appropriate treatment sequence. (Korean J Gastroenterol 2019;73:124-131)

KCI등재 SCOPUS

32018년 대한간학회 만성 B형간염 진료 가이드라인 소개: 2015년 가이드라인과 달라진 점을 중심으로

저자 : 김지훈 ( Ji Hoon Kim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 132-140 (9 pages)

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The clinical practice guideline for the management of chronic hepatitis B (CHB) was originally enacted in 2004 by the Korean Association for the Study of the Liver in order to provide medical practitioners with specific medical information regarding CHB to help them facilitate their understanding of the disease and treatment of the infected patients. Other than an update on the treatment of antiviral resistance in 2014, which is a partial revision, the guidelines for the treatment of chronic hepatitis B have been revised entirely three times in 2007, 2011, and 2015. Although several major international liver association have established and revised clinical practice guidelines, since the medical environment in each country is somewhat different depending on race, region, institution, and economic conditions, it is necessary to revise the Korean guidelines to that reflect our medical environment and own research results. In this review, major change and its background will be summarized about 2018 updated clinical practice guidelines for the management of CHB. (Korean J Gastroenterol 2019;73:132-140)

KCI등재 SCOPUS

4진단 전 흡연과 음주 행태와 위암 환자의 생존율: 전향적 환자 코호트 연구

저자 : 김신아 ( Shin Ah Kim ) , 최보율 ( Bo Youl Choi ) , 송규상 ( Kyu Sang Song ) , 박찬혁 ( Chan Hyuk Park ) , 은창수 ( Chang Soo Eun ) , 한동수 ( Dong Soo Han ) , 김용성 ( Yong Sung Kim ) , 김현자 ( Hyun Ja Kim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 141-151 (11 pages)

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Background/Aims: Behavioral factors, such as smoking and heavy alcohol consumption, increase the risk of gastric cancer (GC), but their effects on survival are not clear. We examined associations between prediagnostic smoking and alcohol drinking behavior and GC death by long-term follow-up.
Methods: The participants were 508 GC patients enrolled at Chungnam University Hospital and Hanyang University Guri Hospital from 2001 to 2006. Information on clinicopathologic and behavioral risk factors was collected, and patient survival was prospectively followed until 2016 by medical chart review and telephone survey.
Results: During above 10 years follow-up period, overall death was 46.2% (n=226) and GC deaths was 38.2% (n=187) among the 489 GC patients included in the analysis. No significant association was found between smoking habits and overall or GC survival. However, after stratification by histological type, the hazard ratio (HR) of GC death for current smokers tended to be higher for the diffuse type (HR 1.61, 95% CI 0.57-4.59 for current vs. never) rather than for the intestinal type (HR 0.78, 95% CI 0.28-2.19 for current vs. never). Light alcohol consumption was found to be associated with a significantly lower risk of GC death (HR 0.52, 95% CI 0.36-0.75 for <20 g/day for women or <40 g/day for men vs. never and past), and the effects of alcohol drinking habits had similar effects on GC death for the intestinal and diffuse types. Conclusions: These results suggest smoking and alcohol drinking behaviors before a diagnosis of GC are weakly associated with GC survival. Nevertheless, the effect of smoking behavior on prognosis appears to depend on the histological type of GC. (Korean J Gastroenterol 2019;73:141-151)

KCI등재 SCOPUS

5인구기반 표준 코호트를 이용한 대장 내시경 후 천공 발생: 후향적, 환자-대조군 연구

저자 : 김지우 ( Ji Woo Kim ) , 김수영 ( Su Young Kim ) , 최정혜 ( Jung Hye Choi ) , 김현수 ( Hyun-soo Kim ) , 이정국 ( Jung Kuk Lee ) , 김윤태 ( Yun Tae Kim ) , 박근우 ( Geunu Park ) , 강대용 ( Dae Ryong Kang )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 152-161 (10 pages)

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Background/Aims: Despite the many reports of colonoscopy complications worldwide, few studies have been performed at the population level in Korea. In this study, a population-based study was performed to evaluate the incidence of post-colonoscopy perforations compared to a control group.
Methods: Between January 2011 and December 2011, data for all cases (age over 45) who underwent a colonoscopy were collected from National Health Insurance Service using a random sampling method. The clinical characteristics and perforation incidence (within 30 days after the colonoscopy) of cases were identified, and cases were then compared with controls who had not undergone a colonoscopy.
Results: Among 1,380,000 subjects, 31,177 cases and 62,354 controls were identified. Perforation occurred in 14 patients (0.04%) in the case group and one patient (<0.01%) in the control group (RR, 28.0; 95% CI 3.7-212.9, p<0.001). Subgroup analysis was followed according to the endoscopic procedure, gender and age. In subgroup analysis, colonoscopy-associated perforations occurred more in the therapeutic procedure (RR, 26; 95% CI 1.46-461.46), male (RR, 50; 95% CI 2.96-844.41), and age of 45-60 years (RR, 30; 95% CI 1.71-525.23). Conclusions: A colonoscopy procedure is related to an increased risk of perforation at the population level. In addition, the therapeutic procedure, male, and

KCI등재 SCOPUS

6우측 대장암 환자에서 현미부수체 불안정성(Microsatellite Instability)의 임상적 의의

저자 : 한서애 ( Seo Ae Han ) , 김재현 ( Jae Hyun Kim ) , 최지훈 ( Ji Hun Choi ) , 이도형 ( Do Hyeong Lee ) , 정경원 ( Kyoungwon Jung ) , 김성은 ( Sung Eun Kim ) , 문원 ( Won Moon ) , 박무인 ( Moo In Park ) , 박선자 ( Seun Ja Park )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 159-166 (8 pages)

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Background/Aims: Colorectal cancer (CRC) with microsatellite instability (MSI) has a better prognosis than CRC with microsatellite stable (MSS). Recent studies have reported biological differences according to tumor location in CRC. In this study, we investigated the clinical significance of MSI in patients with right-sided CRC.
Methods: The medical records of 1,009 CRC patients diagnosed at our institute between October 2004 and December 2016 with MSI test results were retrospectively reviewed. The long-term outcomes of CRC patients with MSI were assessed with respect to tumor location using Kaplan-Meier curves and Cox regression models.
Results: The median follow-up duration for all 1,009 study subjects was 25 months (interquartile range, 15-38). One hundred twenty- four of the study subjects had MSI (12.3%) and 250 had right-sided CRC (24.8%). The patients with MSI and right-sided CRC had better disease-free survival (DFS) than those with MSS as determined by the log-rank test (p=0.013), and this result was significant in females (p=0.035) but not in males with right-sided CRC. Multivariate Cox regression analysis showed MSS significantly predicted poor DFS in patients with right-sided CRC (hazard ratio 3.97, 95% CI 1.30-12.15, p=0.016) and in female patients (hazard ratio 4.69, 95% CI 1.03-21.36, p=0.045). Conclusions: The study shows MSI is a useful predictor of DFS in patients with right-sided CRC, especially in female patients. (Korean J Gastroenterol 2019;73:159-166)

KCI등재 SCOPUS

7Barcelona Clinic Liver Cancer 병기A 간세포암 환자에서 경동맥화학색전술과 고주파열치료술 병용 요법의 효과와 안전성

저자 : 김아란 ( Ah Ran Kim ) , 박유진 ( Eugene Park ) , 권소영 ( So Young Kwon ) , 박성준 ( Seong Jun Park ) , 김영중 ( Young Jung Kim ) , 유병철 ( Byung Chul Yoo ) , 최원혁 ( Won Hyeok Choe ) , 김정한 ( Jeong Han Kim ) , 황진호 ( Jin Ho Hwang ) , 박상우 ( Sang Woo Park ) , 김영준 ( Young Jun Ki

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 167-176 (10 pages)

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Background/Aims: Surgical resection or ablation is recommended for the treatment of early hepatocellular carcinoma (HCC), whereas transarterial chemoembolization (TACE) is frequently used in early HCC ineligible for curative resection. We evaluated the clinical effects and safety of radiofrequency ablation (RFA) shortly after TACE in patients with Barcelona clinic liver cancer (BCLC) stage A HCC.
Methods: Sixty-seven BCLC stage A HCC patients who failed to achieve complete response to TACE as either a first line treatment and who subsequently received RFA at the Konkuk University Medical Center from January 2005 to December 2017 were included. Evaluation indices included treatment response, overall survival rate, recurrence-free survival, prognostic factors, and procedure-related complications.
Results: Median follow-up was 46.9 months. Fifty-four (80.6%) patients were of Child-Pugh class A, and 13 (19.4%) were of class B. Modified UICC stages were I in 10 (14.9%), II in 46 (68.7%), and III in 11 (16.4%) patients. In the 67 study subjects, cumulative recurrence-free survival rates were 86.8%, 55.9% and 29.7% at 1, 3, and 5 years, respectively, and overall survival rates were 100%, 93.4%, and 83.5% at 1, 3, and 5 years, respectively. Tumor size significantly predicted recurrence. No treatment-related death occurred.
Conclusions: Combination of RFA was an efficient and safe treatment for BCLC stage A HCC patients that failed to achieve complete response to initial TACE. We suggest TACE plus RFA be considered as a curative option for early HCC patients ineligible for curative resection of RFA. (Korean J Gastroenterol 2019;73:167-176)

KCI등재 SCOPUS

8악성 위궤양과 감별이 어려웠던 Epstein-Barr Virus 감염이 동반된 양성 위궤양 증례 1예

저자 : 곽진욱 ( Jin Wuk Gwak ) , 유지원 ( Jiwon Yoo ) , 서승오 ( Seong O Suh ) , 김재연 ( Jaeyeon Kim ) , 오인수 ( In Soo Oh ) , 배지윤 ( Ji Yoon Bae )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 177-181 (5 pages)

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Epstein-Barr virus (EBV) is the cause of infectious mononucleosis, which is characterized by fever, lymphadenopathy, and sore throat. On the other hand, gastrointestinal symptoms of EBV infection like dyspepsia, abdominal pain are non-specific and rarely encountered, which means it is difficult to diagnose gastric involvement of EBV infection without suspicion. The relation between gastric carcinoma and gastric lymphoma associated with EBV infection is well defined, but relations with other EBV-associated gastrointestinal diseases such as gastritis and peptic ulcer disease have rarely been reported. We report a case of benign gastric ulcer with EBV infection confirmed by endoscopic and histological findings. (Korean J Gastroenterol 2019;73:177-181)

KCI등재 SCOPUS

9췌장으로 전이한 자궁경부선암 1예

저자 : 김도준 ( Do Jun Kim ) , 박진명 ( Jin Myung Park ) , 김지현 ( Ji Hyun Kim ) , 남길우 ( Kilwoo Nam ) , 강창돈 ( Chang Don Kang ) , 이성준 ( Sung Joon Lee ) , 이경열 ( Kyoungyul Lee ) , 전용환 ( Yong Hwan Jeon )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 182-185 (4 pages)

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Pancreatic metastasis from cervical cancer is extremely rare. We report a case of metastatic adenocarcinoma of the pancreas from uterine cervical cancer. A 70-year-old woman was referred because of a pancreatic mass detected by CT. She had been diagnosed with uterine cervical adenocarcinoma 20 months previously. After concurrent chemoradiotherapy, CT showed no evidence of the cervical mass, and follow-up showed no evidence of recurrence. Endoscopic ultrasound-guided fine needle aspiration biopsy of the pancreatic mass resulted in a diagnosis of metastatic adenocarcinoma from uterine cervix. (Korean J Gastroenterol 2019;73:182-185)

KCI등재 SCOPUS

10중환자에서 발생하는 이차성 경화성 담관염

저자 : 박남영 ( Namyoung Park ) , 백우현 ( Woo Hyun Paik )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 73권 3호 발행 연도 : 2019 페이지 : pp. 186-189 (4 pages)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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(2006)홍길동심리학41회 피인용

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(2006)홍길동41회 피인용

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