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대한소화기학회지 update

The Korean Journal of Gastroenterology

  • : 대한소화기학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 월간
  • : 1598-9992
  • : 2233-6869
  • : 대한소화기병학회잡지(~1989) → 대한소화기병학회지(1990~) → 대한소화기학회지(1995~)

수록정보
수록범위 : 1권1호(1968)~76권3호(2020) |수록논문 수 : 5,633
대한소화기학회지
76권3호(2020년 09월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1염증성 장질환에서 Arthrospira (Spirulina) platensis의 유용성

저자 : 김지현 ( Ji Hyun Kim ) , 박성철 ( Sung Chul Park )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 99-101 (3 pages)

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KCI등재 SCOPUS

2담낭 용종의 진단, 치료 및 추적 관찰의 최신 지견

저자 : 장성일 ( Sung Ill Jang ) , 조재희 ( Jae Hee Cho ) , 이동기 ( Dong Ki Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 102-107 (6 pages)

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A gallbladder (GB) polyp is an elevation of the GB mucosa that protrudes into the GB lumen. GB polyps have an estimated prevalence of 0.3-9.5% and can be divided into neoplastic (true) polyps and nonneoplastic polyps (pseudopolyps). Pseudopolyps are most commonly cholesterol polyps but also include focal adenomyomatosis and inflammatory polyps with no malignant potential. Neoplastic polyps, however, can be benign or malignant. Benign polyps are most commonly adenomas, while malignant polyps are usually adenocarcinoma. Transabdominal ultrasonography is the main radiological modality used for diagnosing and surveilling GB polyps. On the other hand, because it is difficult to diagnose GB polyps before surgery, alternative imaging modalities, such as endoscopic ultrasound, are being further evaluated. The current guidelines recommend cholecystectomy for GB polyps ≥ 10 mm in size as well as suboptimal sized GB polyps (6-9 mm) with other risk factors, including age >50, sessile, and symptoms. The quality of the evidence behind this practice is relatively low. Therefore, this review identifies the current gaps in the available evidence and guidelines and introduces methods that can help make decisions regarding patients who require a cholecystectomy or follow-up. (Korean J Gastroenterol 2020;76:102-107)

KCI등재 SCOPUS

3약제 연관 소화성궤양의 임상 진료지침 개정안 2020

저자 : 주문경 ( Moon Kyung Joo ) , 박찬혁 ( Chan Hyuk Park ) , 김준성 ( Joon Sung Kim ) , 박재명 ( Jae Myung Park ) , 안지용 ( Ji Yong Ahn ) , 이봉은 ( Bong Eun Lee ) , 이정훈 ( Jeong Hoon Lee ) , 양효준 ( Hyo-joon Yang ) , 조유경 ( Yu Kyung Cho ) , 방창석 ( Chang Seok Bang ) , 김범진 ( Beom Jin

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 108-162 (55 pages)

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The Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcers were previously developed under co-work with the Korean College of Helicobacter and Upper Gastrointestinal Research and Korean Society of Gastroenterology at 2009. On the other hand, the previous guidelines were based mainly on a literature review and expert opinions. Therefore, the guidelines need to be revised. In this study, a guideline development committee for drug-induced peptic ulcers was organized under the Korean College of Helicobacter and Upper Gastrointestinal Research in 2017. Nine statements were developed, including four for NSAID, three for aspirin and other antiplatelet agents, and two for anticoagulants through de novo processes based on evidence-based medicine, such as a literature search, meta-analysis, and the consensus was established using the modified Delphi method. The primary target of this guideline was adult patients taking long-term NSAIDs, aspirin, or other antiplatelet agent and anticoagulants. The revised guidelines reflect the consensus of expert opinions and are intended to assist relevant clinicians in the management and prevention of drug-induced peptic ulcers and associated conditions. (Korean J Gastroenterol 2020;76:108-133)

KCI등재 SCOPUS

4식도열공탈장이 없는 환자에서 내시경을 통한 산역류의 예측

저자 : 김준영 ( Jun Young Kim ) , 신인섭 ( In Seub Shin ) , 민양원 ( Yang Won Min ) , 김경아 ( Kyunga Kim ) , 이혁 ( Hyuk Lee ) , 민병훈 ( Byung-hoon Min ) , 이준행 ( Jun Haeng Lee ) , 김재준 ( Jae J. Kim ) , 이풍렬 ( Poong-lyul Rhee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 134-141 (8 pages)

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Background/Aims: A diagnosis of gastroesophageal reflux disease is challenging in patients who have reflux symptoms but do not respond to proton pump inhibitors nor have reflux esophagitis and hiatal hernia (HH) on endoscopy. This study examined the predictive role of the endoscopic findings, including the flap valve grade for pathologic acid exposure (PAE) to establish an endoscopic prediction model in patients with neither reflux esophagitis nor HH.
Methods: Five hundred seventy-eight patients who underwent upper endoscopy and 24 hours pH monitoring for reflux esophageal symptoms without evidence of reflux esophagitis and HH were analyzed. The gastroesophageal flap valve (GEFV), esophageal metaplasia, and chronic atrophic gastritis were assessed. The association between the endoscopic parameters and PAE was evaluated.
Results: Four hundred ninety-four patients were enrolled. The most common complaint was chest discomfort (42.3%) followed by globus (31.8%), dysphagia (7.9%), and heartburn (7.7%). PAE was present in 43 patients (8.7%). Multivariable analysis revealed PAE to be associated with the GEFV grade (p<0.001) and inversely associated with the chronic atrophic gastritis grade (p=0.005). Using these features, a predictive model was established and showed an area under the receiver operating characteristic curve of 0.705 (95% CI 0.619-0.790). The cutoff value of 12.0 had a sensitivity and specificity of 44.0% and 84.0%, respectively.
Conclusions: A loosened GEFV is associated with a risk of PAE in patients with neither reflux esophagitis nor HH, while atrophic gastritis is preventive. On the other hand, the endoscopic predictive model revealed a low sensitivity for detecting PAE. Thus, reflux testing needs to be performed further when gastroesophageal reflux disease is suspected, even without endoscopic evidence. (Korean J Gastroenterol 2020;76:134-141)

KCI등재 SCOPUS

5헬리코박터 파일로리 감염의 일차 치료로써 7일 고용량 Esomeprazole 포함 표준 삼제 요법과 7일 표준 삼제 요법의 제균율 비교 연구

저자 : 이영달 ( Young Dal Lee ) , 김성은 ( Sung Eun Kim ) , 박선자 ( Seun Ja Park ) , 박무인 ( Moo In Park ) , 문원 ( Won Moon ) , 김재현 ( Jae Hyun Kim ) , 정경원 ( Kyoungwon Jung ) , 송지윤 ( Jiyun Song )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 142-149 (8 pages)

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Background/Aims: The rates of Helicobacter pylori (H. pylori) eradication have declined with the use of proton pump inhibitor- amoxicillin-clarithromycin as the first-line triple therapy. On the other hand, several studies have suggested that high gastric pH levels could affect the H. pylori eradication rate by enhancing the efficacy of antimicrobials. This study compared the efficacy of seven-day high-dose esomeprazole-based triple therapy (7-HEAC) for first-line H. pylori eradication with the seven-day standard dose non-esomeprazole-based triple therapy (7-NEAC) to identify the risk factors related to eradication failure.
Methods: This study included 223 patients who were diagnosed with a H. pylori infection and received 7-HEAC or 7-NEAC between June 2016 and January 2017. The H. pylori eradication rates, as well as demographic and clinical factors, were investigated retrospectively. H. pylori eradication was confirmed by a 13C-urea breath test or rapid urease test at least 4 weeks after the completion of therapy.
Results: The eradication rates were 67.7% (105/155; 95% CI 59.5-74.8%) in the 7-NEAC group and 80.9% (55/68; 95% CI 69.9-89.8%) in the 7-HEAC group (p=0.045). The adverse event rates were 5.8% (9/155) in the 7-NEAC group and 7.4% (5/68) in the 7-HEAC group (p=0.661). Multivariate analysis revealed being female (OR 2.08; 95% CI 1.15-3.76) to be associated with the failure of H. pylori eradication therapy.
Conclusions: The eradication rate of the 7-HEAC group was higher than that of the 7-NEAC group. Nevertheless, more effective first-line therapies may be necessary for H. pylori eradication in the near future. (Korean J Gastroenterol 2020;76:142-149)

KCI등재 SCOPUS

6Arthrospira (Spirulina) platensis Attenuates Dextran Sulfate Sodium-induced Colitis in Mice by Suppressing Key Pro-inflammatory Cytokines

저자 : Francisca Adilfa De Oliveira Garcia , Helioswilton Sales-campos , Violet G. Yuen , Juliana Reis Machado , Glauce Socorro De Barros Viana , Carlo José Freire Oliveira , John H. Mcneill

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 150-158 (9 pages)

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Background/Aims: Therapies aimed at modulating cytokines have been used to treat inflammatory illnesses, such as inflammatory bowel disease. On the other hand, patients may become intolerant, refractory, or present with several side effects. Arthrospira (Spirulina) platensis (SPI) is a blue-green microalga with bioactive molecules that have been evaluated to treat inflammatory diseases. On the other hand, few studies have examined their effects on the production of specific cytokines and the intestinal architecture in dextran sulfate sodium (DSS)-induced colitis. Therefore, this study examined the effects of a treatment using SPI in a murine model of intestinal inflammation.
Methods: All mice (C57BL/6 male) were evaluated daily for their food and water intake, bodyweight variations, and clinical signs of disease. Colon inflammation was induced by exposure to DSS for 6 consecutive days. SPI was given orally at 50, 100, and 250 mg/kg/day. ELISA was performed to assess the production of cytokines. Myeloperoxidase and nitric oxide were also investigated. The level of microscopic damage was assessed by staining colon sections with hematoxylin and eosin.
Results: SPI attenuated the DSS-induced inflammation, with improvements in the clinical signs and a decrease in the production of inflammatory cytokines, such as tumor necrosis factor-α and interferon-γ. In addition, particularly at 250 mg/kg, SPI attenuated the severity of colitis by modulating the level of mucosal and submucosal cell infiltration, which preserved the epithelial barrier.
Conclusions: SPI may be an alternative source of bioactive molecules with immunomodulatory properties, and has great potential to be used in the treatment of inflammatory diseases. (Korean J Gastroenterol 2020;76:150-158)

KCI등재 SCOPUS

7내시경적 점막 절제술로 치료한 동시성 대장암이 동반된 거치상 폴립증 증후군

저자 : 이상훈 ( Sang Hoon Lee ) , 이성준 ( Sung Joon Lee ) , 박성철 ( Sung Chul Park ) , 남승주 ( Seung-joo Nam ) , 강명호 ( Myeong Ho Kang ) , 김태석 ( Tae Suk Kim ) , 이승구 ( Seung Koo Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 159-163 (5 pages)

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Serrated polyposis syndrome (SPS) can transform to malignant lesions through the sessile serrated pathway and traditional serrated pathway. These pathways may cause rapid neoplastic progression compared to the adenoma-carcinoma sequence, which may cause interval colorectal cancer. The authors experienced a case of SPS with a synchronous colon adenocarcinoma that was treated with an endoscopic mucosal resection. In pathology reviews, other parts of the adenocarcinoma showed sessile serrated adenoma. Therefore, patients with SPS have a potential for malignant transformation, highlighting the need for strict colonoscopy surveillance starting at the time of SPS diagnosis. (Korean J Gastroenterol 2020;76:159-163)

KCI등재 SCOPUS

8Acute Intestinal Ischemia in a Patient with COVID-19 Infection

저자 : Balraj Singh , Ashesha Mechineni , Parminder Kaur , Nora Ajdir , Michael Maroules , Fayez Shamoon , Mahesh Bikkina

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 164-166 (3 pages)

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The World Health Organization has declared novel coronavirus disease 2019 (COVID-19) a global public health emergency. Although respiratory symptoms predominate in COVID-19, thrombosis can occur in patients with COVID-19. This paper reports a case of an 82-year-old female with a prior medical history of hypertension, diabetes presenting with fever and cough, and was diagnosed with COVID-19. The patient subsequently developed progressively worsening of abdominal distention, tenderness, and underwent emergent laparotomy. She was found to have a gangrenous colon. This case adds to the limited literature regarding the extrapulmonary complications of COVID-19. (Korean J Gastroenterol 2020;76:164-166)

KCI등재 SCOPUS

9동화 남성화스테로이드 유사체 남용 후 발생한 중증 지속 황달

저자 : 고현길 ( Hyun Gil Goh ) , 이유진 ( Yoo Jin Lee ) , 김태형 ( Tae Hyung Kim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 167-170 (4 pages)

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Hepatic disorders with prominent cholestasis can be caused by a range of conditions, and anabolic androgenic steroids have been considered a cause of protracted cholestasis. A 29-year-old man who had taken an anabolic androgenic steroid analogue for 2 months visited the hospital complaining of jaundice and indigestion. After stopping the medication, the hyperbilirubinemia tended to decrease, but a transiently elevated aminotransferase level was observed. The endogenous testosterone level also decreased initially but recovered soon after. The liver function profiles were normalized after 2 months of conservative management. This case emphasizes that close drug history taking, including anabolic steroids, is important for identifying the cause of unexplained persistent jaundice. (Korean J Gastroenterol 2020;76:167-170)

KCI등재 SCOPUS

10미만성 미세 결절 형태로 나타난 점막슈반세포과오종

저자 : 장한별 ( Han Beol Jang ) , 김종옥 ( Jong Ok Kim ) , 강상범 ( Sang-bum Kang )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 76권 3호 발행 연도 : 2020 페이지 : pp. 171-173 (3 pages)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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