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대한소화기학회지 update

The Korean Journal of Gastroenterology

  • : 대한소화기학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 월간
  • : 1598-9992
  • : 2233-6869
  • : 대한소화기병학회잡지(~1989)→대한소화기병학회지(1990~)→대한소화기학회지(1995~)

수록정보
수록범위 : 1권1호(1968)~74권1호(2019) |수록논문 수 : 5,490
대한소화기학회지
74권1호(2019년 07월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1우리나라 위 상피성 용종 발생의 원인적 인과성

저자 : 이혁 ( Hyuk Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 1-3 (3 pages)

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2조기발병 대장암

저자 : 정모아 ( Mo Ah Jeong ) , 강현우 ( Hyoun Woo Kang )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 4-10 (7 pages)

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The incidence of colorectal cancer (CRC) is increasing among young adults in several countries including the United States. Early-onset colorectal cancer (EO-CRC) is heterogenous group and appears to have a distinct clinical, pathologic, and molecular presentation compared to CRC diagnosed in older patients. EO-CRC patients tend to be diagnosed at later stage and with symptomatic disease. Tumors arise predominantly in the distal colon and rectum and have poorer histological features. Microsatellite and chromosome stable molecular pathway is frequently observed in EO-CRC. Survival data of EO-CRC is conflicting and younger patients tend to be treated more aggressively. It is important to identify high risk and have them screened appropriately to address increasing EO-CRC. Screening and treatment strategies for EO-CRC should be developed through further investigation of molecular mechanism and various environmental risk factors. In Korea, EO-CRC and late-onset CRC have both declined in recent several years, probably due to many screening colonoscopies in young population. Close observation and analysis of EO-CRC in Korea is necessary. (Korean J Gastroenterol 2019;74:4-10)

KCI등재 SCOPUS

3바렛식도와 이형성증, 조기식도선암의 진단과 치료: 미국과 유럽의 임상지침을 중심으로

저자 : 유아영 ( Ah Young Yoo ) , 주문경 ( Moon Kyung Joo )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 11-16 (6 pages)

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Barrett's esophagus (BE) is one of the most prominent diseases in Western countries because of its potential to progress to dysplasia or adenocarcinoma. Recently, the American College of Gastroenterology (ACG), American Gastroenterology Association (AGA), and European Society of Gastrointestinal Endoscopy (ESGE) developed clinical guidelines for the diagnosis and management of BE. All three guidelines commonly stressed the necessity of the endoscopic eradication of confirmed, nonnodular low grade dysplasia or high grade dysplasia, as well as the endoscopic elimination of the remaining BE after an endoscopic resection of visible mucosal abnormalities. An endoscopic resection is also considered for the optimal management of esophageal adenocarcinoma confined to the mucosa (T1a), and even in selective cases of submucosal invasion (T1b). As endoscopic therapy becomes the mainstay for the treatment of BE and its complications, the eligibility of pathologic or endoscopic experts and the BE expert center are being set and strengthened. This paper introduces the statements of the ACG, AGA and ESGE guidelines and compares the similarities and differences between them. (Korean J Gastroenterol 2019;74:11-16)

KCI등재 SCOPUS

4다발성 위용종의 조직학적 분류에 따른 위험인자: 전향적 코호트 연구

저자 : 정찬영 ( Chan Young Jeong ) , 김나영 ( Nayoung Kim ) , 이혜승 ( Hye Seung Lee ) , 윤혁 ( Hyuk Yoon ) , 신철민 ( Cheol Min Shin ) , 박영수 ( Young Soo Park ) , 김진욱 ( Jin-wook Kim ) , 이동호 ( Dong Ho Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 17-29 (13 pages)

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Background/Aims: The aim of this study was to determine the risk factors of multiple gastric polyps according to the histological classification of gastric polyps.
Methods: Subjects with multiple gastric polyps (at least three) during endoscopy were enrolled prospectively. They were assigned to a fundic gland polyp (FGP) group and hyperplastic polyp (HP) group based on a histological classification of gastric polyps. Helicobacter pylori (H. pylori) was confirmed by its histology. Serum gastrin was measured using the radioimmunoassay method. A questionnaire was taken regarding the intake of proton pump inhibitor and nonsteroidal anti-inflammatory drugs, alcohol, smoking history, and diet.
Results: Among the 60 subjects enrolled from 2015 to 2018 at Seoul National University Bungdang Hospital, 47 and 13 subjects were assigned to the FGP and HP groups, respectively. The H. pylori infection rate was 12.8% in the FGP group, which is lower than that in the HP group (69.2%, p<0.001). The gastrin level was higher in the HP group (194.7 pg/dL, range 50.6-387.8 pg/dL) than in the FGP group (57.4 pg/dL, range 24.8-79.0 pg/dL) (p=0.007). Histologically, neutrophil infiltration in the antrum and body of the stomach were higher in the HP group than in the FGP group (p=0.022 and p=0.030, respectively). In contrast, monocyte infiltration in the antrum and body of the stomach were higher in the FGP group than in the HP group (p=0.018 and p<0.001, respectively).
Conclusions: HPs arise from inflammation caused by H. pylori. On the other hand, the FGP was not associated with H. pylori or environmental factors. (Korean J Gastroenterol 2019;74:17-29)

KCI등재 SCOPUS

5파지 디스플레이를 이용한 췌장암 특이적 결합 펩타이드 개발

저자 : 이동원 ( Dong Won Lee ) , 박재명 ( Jae Myung Park ) , 양승목 ( Seung Mok Yang ) , 곽문화 ( Moon Hwa Kwak ) , 노윤진 ( Yoon Jin Roh ) , 이인석 ( In Seok Lee ) , 최명규 ( Myung-gyu Choi )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 30-41 (12 pages)

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목적: 췌장암은 예후가 매우 불량한 암으로, 조기 진단이 환자의 생존율을 높일 수 있는 방법이나 진단에 특이적 증상은 없다. 이번 연구는 영상학적 진단에 사용할 수 있는 췌장암 특이적 펩타이드를 개발하고자 하였다.
대상 및 방법: 7-mer 파지 디스플레이 라이브러리를 이용하여 3회의 bio-panning을 췌장암 세포주인 MIA PaCa-2, UACC-462, BxPC-3에서 실시하였다. 증폭된 파지로 췌장암 세포주들과 대조세포인 CCD841 세포주에서 면역효소법과 면역화학염색을 시행하여, 췌장암 세포에 특이적으로 결합하는 파지를 선택하였다. 합성된 펩타이드에 FITC로 표지한 후면역형광염색 및 FACS로 췌장암 특이도를 조사하였다. 치료적 사용 가능성 탐색을 위하여 개발된 펩타이드에 광감각제인 Ce6를 결합하였고, 이 결합체를 MIA PaCa-2와 CCD841 세포주에 전처리 및 레이저(3 J/cm2) 조사 24시간 후에 MTT로 세포 생존율을 분석하였다. 실험실적 결과를 췌장암 세포주이식 모델에서 다시 확인하였다.
결과: 췌장암 세포주에서 3번의 bio-panning을 시행하여, 첫회의 파지 회수율 1.4×104 pfu에서 세 번째에는 3.2×105 pfu로 증가되었다. 증폭된 파지 클론으로 면역효소법 및 면역화학염색을 시행하여 췌장암 세포주 MIA PaCa-2에 특이적 결합을 보이는 파지(M5)를 선택하였다. M5의 아미노산 서열(WLEVYLG)로부터 펩타이드를 합성하였다. FITC가 표지된 펩타이드 M5는 CCD841에 비하여 MIA PaCa-2에서 높은 형광을 보여주었고, FACS 분석에서도 우측 이동을 확인하였다. Ce6와 결합된 M5는 Ce6 단독에 비하여 광역학 치료에서 유의하게 낮은 세포 생존율을 보였다. MIA PaCa-2 세포주를 이식한 동물실험에서도 M5와 결합한 Ce6가 Ce6 단독군에 비하여 유의하게 높은 종양 특이적 형광발현 및 광역학 치료반응을 보여주었다.
결론: 이번 연구로 펩타이드 M5가 췌장암 세포주 MIA PaCa-2에 특이적으로 결합함을 확인하였으며, 이를 이용하여 영상학적 진단 및 치료 목적으로 사용 가능할 것으로 생각되었다.


Background/Aims: Pancreatic cancer has a very poor prognosis, and early diagnosis is a way to increase the survival rate of patients. The purpose of this study was to develop pancreatic cancer-specific peptides for imaging studies.
Methods: Three pancreatic cancer cell lines, MIA PaCa-2, UACC-462, and BxPC-3, and a control cell line, CCD841, were used. Biopannings were performed on MIA PaCa-2 using a phage display library. After this, the peptides were synthesized and labeled with fluorescein isothiocyanate (FITC). Immunocytochemistry (ICC), enzyme-linked immunosorbent assay (ELISA), and fluorescence- activated cell sorter (FACS) were performed to examine the specific binding. To examine its therapeutic applications, a photosensitizer, chlorin e6 (Ce6), was conjugated on the peptide and photodynamic therapy was performed. Cell survival was investigated using a [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] assay.
Results: After three biopannings, the phages were amplified from 1.4×104 to 3.2×105 plaque-forming units. The most strongly binding phage was selected from the ELISA and ICC results. FITC-labeled peptide, M5, in the three pancreatic cancer cell lines showed significantly higher immunofluorescence in the ICC experiments than that of CCD841. The higher binding ability to MIA PaCa-2 cells was confirmed from FACS analysis, which showed a right shift compared to CCD841. M5 bound to Ce6 showed a significantly lower cell survival rate than that of Ce6 alone in photodynamic therapy, which was observed consistently as a change in the tumor size and fluorescence intensity in MIA PaCa-2 cell-implanted animal models.
Conclusions: This study showed that the noble peptide, M5, binds specifically to the pancreatic cancer cell line, MIA PaCa-2. The M5 peptide has potential use in future optical diagnostic and therapeutic purposes. (Korean J Gastroenterol 2019;74:30-41)

KCI등재 SCOPUS

6소아에서 소장 내시경으로 제거한 라푼젤 증후군 1예

저자 : 천상우 ( Sang Woo Chun ) , 이건송 ( Kunsong Lee ) , 박윤준 ( Youn Joon Park ) , 신현덕 ( Hyun Deok Shin )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 42-45 (4 pages)

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A trichobezoar is a type of bezoar that is composed of hair. In most cases, it is confined to the stomach, but in rare cases, it may extend to the small intestine. This condition is referred to as Rapunzel syndrome. The therapeutic method for bezoar removal depends on its type, location, and size. Generally, the treatment for Rapunzel syndrome involves surgical laparotomy. Endoscopic removal has also been effective in some cases. On the other hand, complications, such as respiratory difficulty and esophageal impaction may be encountered during endoscopic removal. Until now, the successful endoscopic removal of trichobezoars has been limited to the stomach or duodenum. This paper reports the case of a 4-year-old female patient with Rapunzel syndrome whose trichobezoar reached the proximal jejunum. The trichobezoar was removed without complications using an electrosurgical knife and snare through a single- balloon enteroscopy. The trichobezoar can be removed successfully using enteroscopy under general anesthesia without abdominal laparotomy in young children. Therefore, this method of removal can be considered preferentially for children with Rapunzel syndrome. (Korean J Gastroenterol 2019;74:42-45)

KCI등재 SCOPUS

7방선균증이 동반된 대장의 미만성 거대 B-세포 림프종 증례

저자 : 이상훈 ( Sang Hoon Lee ) , 남승주 ( Seung-joo Nam ) , 이성준 ( Sung Joon Lee ) , 박성철 ( Sung Chul Park ) , 강창돈 ( Chang Don Kang ) , 최대희 ( Dae Hee Choi ) , 박진명 ( Jin Myung Park ) , 이승구 ( Seung Koo Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 46-50 (5 pages)

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Actinomycosis can mask malignant diseases. This paper reports a case of colonic diffuse large B-cell lymphoma (DLBCL), which was misdiagnosed as abdominal actinomycosis. A 76-year-old woman presented with right flank pain and weight loss. Abdominal CT and colonoscopy revealed a huge ascending colon mass. Despite the initial impression of a malignancy, a colonoscopic biopsy revealed no malignant cells, but sulfur granules and a filamentous organism suggesting actinomycosis. Intravenous penicillin G was administered under the impression of abdominal actinomycosis but her condition deteriorated rapidly. Follow up CT showed markedly increased colon mass and new multiple nodular lesions around the ascending colon. Sono-guided percutaneous biopsy of the nodular lesion was performed. The pathological result was DLBCL. The patient was scheduled to undergo chemotherapy but the patient expired due to cancer progression. The diagnosis of gastrointestinal infiltrating tumors is often difficult because a superficial biopsy usually does not provide a confirmative diagnosis. This case highlights the difficulty in making a correct diagnosis of lymphoma due to the concomitant actinomycosis. Malignant conditions must be considered in cases of actinomycosis with no response to antimicrobial therapy. (Korean J Gastroenterol 2019;74:46-50)

KCI등재 SCOPUS

8충수돌기에 감돈되어 괴사를 일으킨 코인 건전지 1예

저자 : 임창범 ( Chang Bum Rim ) , 송경호 ( Kyung Ho Song )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 51-56 (6 pages)

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Coin batteries are often used in daily life devices and can be easily available. Children can swallow coin batteries, resulting in the need to go to hospital, but this is rare in adults. Adults generally eliminate the swallowed coin battery from the digestive system, unless they have congenital structural abnormalities of the digestive system or complications, such as postoperative stenosis. In this case, a 31-year-old man swallowed three coin batteries, approximately 0.4 cm in diameter emergent endoscopy was unable to find any batteries embedded in the ingested food. An attempt was made to rinse out the batteries by bowel preparation. During the hospital stay, the patient complained of acute abdominal pain and fever. In the abdominal CT scan, impaction of the coin battery into the appendix was confirmed. The patient underwent a laparoscopic appendectomy to prevent appendiceal perforation. (Korean J Gastroenterol 2019;74:51-56)

KCI등재 SCOPUS

9흉추와 간에 동시 발생한 원발성 평활근육종

저자 : 김영관 ( Young Kwan Kim ) , 김정아 ( Jung-a Kim ) , 류수형 ( Soo Hyung Ryu ) , 최종현 ( Jong Hyun Choi ) , 총배천 ( Pei Chuan Tsung ) , 박종혁 ( Jong Hyeok Park ) , 문정섭 ( Jeong Seop Moon ) , 심재찬 ( Jae Chan Shim ) , 이혜경 ( Hye Kyung Lee ) , James Matthew Loutzenhiser

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 57-62 (6 pages)

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This is a case report of simultaneous primary leiomyosarcomas in the spine and liver. A 64-year-old woman presented to the Seoul Paik Hospital with epigastric discomfort and constipation that she had experienced for two months. A physical examination revealed severe tenderness around the thoraco-lumbar junction. Esophagogastroduodenoscopy showed an ulceroinfiltrative lesion on the gastric angle. An abdominopelvic CT scan revealed two low attenuated lesions in the S4 and S8 regions of the liver, as well as a soft tissue mass at the T10 vertebra. Percutaneous ultrasonography-guided needle biopsy of the hepatic nodules revealed a leiomyosarcoma. The tumor at the T10 vertebra was removed to avoid spinal cord compression. The histology of this tumor was compatible with that of leiomyosarcoma. The potential primary sites for leiomyosarcoma, including the lung, thyroid, breast, kidney, genitourinary organs, and gastrointestinal tract, were subsequently investigated. No detectable abnormal findings that would suggest the origin of the tumor were found. Synchronous primary leiomyosarcomas in the spine and liver are quite rare and have a poor prognosis. (Korean J Gastroenterol 2019;74:57-62)

KCI등재 SCOPUS

10담췌관의 확장을 동반한 췌장의 장액성 낭샘종 1예

저자 : 김승범 ( Sung Bum Kim ) , 김국현 ( Kook Hyun Kim ) , 김태년 ( Tae Nyeun Kim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 1호 발행 연도 : 2019 페이지 : pp. 63-65 (3 pages)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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(2006)홍길동심리학41회 피인용

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(2006)홍길동41회 피인용

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