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대한한방부인과학회지 update

The Journal Of Oriental Gynecology

  • : 대한한방부인과학회
  • : 의약학분야  >  기초한의학
  • : KCI등재
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  • : 연속간행물
  • : 계간
  • : 1229-4292
  • : 2508-3619
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수록정보
수록범위 : 1권1호(1987)~32권3호(2019) |수록논문 수 : 1,150
대한한방부인과학회지
32권3호(2019년 08월) 수록논문
최근 권호 논문
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KCI등재

1난소적출 마우스를 이용한 골다공증 개선효과를 나타내는 파극천(巴戟天)과 육종용(肉蓗蓉) 열수(熱水) 추출물(抽出物)의 복합 최적 조성 선택 실험

저자 : 안뜰에봄 ( Tteul-e-bom An ) , 김동철 ( Dong-chul Kim )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 1-19 (19 pages)

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Objectives: To select the optimal ranges showing obvious synergic anti-osteoporotic potential after adjust mixed formula consisted of (MR) and Herba (CH) as compared wih those of each single formula or risedronate sodium (RES) using bilateral ovariectomized (OVX) female mice.
Methods: Fourteen groups, total eight sham or 104 OVX mice were selected based on the body weights at 34 days after OVX sugey. After that, 9 types mixed compositions, single formula of MR and CH, and RES were orally administered for 35 days. And we measured changes in body weight and gain, femur weight, bone mineral density (BMD), bone strength (failure load) and mineral content - calcium ( Ca) and inorganic phosphorus (IP), osteocalcin contents and bone specific alkaline phosphatase (bALP) activities of all mice.
Results: The OVX-induced estrogen-deficient osteoporotic signs were significantly inhibited by 35 days of continuous oral treatment of all treated mice as compared with OVX control mice. Especially, MR:CH 1:3 and 1:1 mixed formula treated mice showed significantly more favorable inhibitory activities against estrogen-deficient osteoporosis symptoms as compared to those of each single formula of MR and CH. Although RES also ameliorated the decreases of the femur BMD, strength and trabecular bone architectures through the inhibited the increases of bone turnover, but they did not critically influenced on the bone formations.
Conclusions: The results suggest that MR:CH 1:3 mixed formula showed somewhat lower anti-resorptive effects as compared to those of RES, but they also showed bone formation effects. therefore, it is expected that MR:CH 1:3 mixture will be promising as a potent protective agents for relieving the osteoporosis in menopausal women.

KCI등재

2혈관내피세포에서 우방자(牛蒡子) 에탄올 추출물의 항염증 효과

저자 : 이윤정 ( Yun-jung Lee ) , 윤정주 ( Jung-joo Yoon ) , 김혜윰 ( Hye-yoom Kim ) , 안유미 ( You-mee Ahn ) , 홍미현 ( Mi-hyeon Hong ) , 손찬옥 ( Chan-ok Son ) , 나세원 ( Se-won Na ) , 이호섭 ( Ho-sub Lee ) , 강대길 ( Dae-gill Kang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 20-31 (12 pages)

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Objectives: The seeds from Arctium la have been considered for its various pharmacological properties, which include anti-carcinogenic, anti-inflammatory, anti-diabetic, and anti-viral activities.
Methods: In the present study, we investigated the anti-inflammatory effect of the ethanol extract from the seeds of Arctium lappa L (EAL) on cytokine-induced vascular inflammation in human umbilical vein endothelial cells (HUVEC).
Results: Pretreatment with EAL significantly decreased tumor necrosis factor alpha (TNF-a)-induced cell adhesion molecules expression such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adesion molecule-1 (VCAM-1), and endothelial-selectin (E-selectin) in a dose-dependent manner. Cell adhesion assay showed that pretreatment with EAL suppressed HUVEC-monocyte adhesion by TNF- over 1 μg/ml concentration. We investigated the involvement of nuclear transcription factor kappa-B (NF-κB) in TNF-a-induced vascular inflammation. NF-κB p65 nuclear expression was induced by TNF-a, however, pretreatment with EAL was attenuated that nuclear translocation. In cytoplasm, EAL was also attenuated TNF-a-induced decrease of inhibitor of KB-a (IκB-a) expression. Moreover, EAL significantly decreased TNF-a-induced production of intracellular reactive oxygen species (ROS).
Conclusions: Taken together, our findings suggest that seeds of L could be a therapeutic herb for prevention of cardiovascular diseases throughout the inhibition of vascular endothelial inflammation.

KCI등재

3대하(帶下)처방 3종의 항염, 항소양, 항균 효능에 관한 실험 연구 : 은화사간탕(銀花瀉肝湯), 소복축어탕(少腹逐瘀湯), 완대탕(完帶湯)

저자 : 이은규 ( Eun-kyu Lee ) , 박찬욱 ( Ohan-wook Park ) , 김수현 ( Soo-hyeon Kim ) , 최유진 ( Yoo-jin Choi ) , 박경미 ( Kyung-mi Park ) , 양승정 ( Seung-jeong Yang ) , 조성희 ( Seong-hee Cho )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 32-56 (25 pages)

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Objectives: The purpose of this study was to investigate the in vitro anti-inflammatory, anti-pruritic and antimicrobial effects of the three herbal prescription (EST, SCT, WDT), which has been traditionally used for treating leukorrhea induced by various infections in the female genital tract.
Methods: In this experiment, the anti-inflammatory effects were evaluated by Nitric oxide (NO), Interlukine-lβ (IL-lβ), Interlukine-2 (IL-2), Interlukine-6 (IL-6), Tumor necrosis factor-a (TNF-a), Prostaglandin E2 (PGE2), Leukotriene B4 (LTB4 production amount and Inducible nitric oxide synthase (iNOS), Nuclear factor kappa B (NF-κB), Cyclooxygenase-2 (COX-2) gene expression levels in RAW264.7 cells. And the anti-pruritic effects were evaluated by Histamine, Acetylcholine (ACh), Acetylcholinesterase (AChE), Substance P production amount in Mast cell/9 (MC/9) and Pheochromocytoma 12 (PC12) cells. The anti-microbial effect was measured by inhibition zone diameter on coli, Staphylococcus minis, Pseudomonas aeruginosa and niger.
Results: As a result of measuring anti-inflammatory efficacy, IL- lβ, IL-2, IL-6, TNF-a, PGE2, and LTB4 production amounts were significantly reduced in the EST, SCT, WDT extraction groups compared with the control group, and significantly decreased the amount of NF-kB, iNOS, and COX-2 gene expression and the amount of Phospho-Inhibitor kappa B alpha (p-IκB-a)/Inhibitor kappa B alpha (IκB-a) and NF-B p65 protein expression. In addition, As a result of measuring the anti-pruritic effect, the amounts of histamine, ACh and Substance P were significantly decreased, and AChE production was slightly decreased, but it's significance did not appear. Finally the anti-microbial effects of EST, SCT, WDT extraction groups against aeruginosa, Candida albicans and Aspergillus was inhibited, however the growth of Escherichia coli and Staphylococcus aureus was not inhibited.
Conclusions: These data suggest that EST, SCT, WDT can be used to treat patients with leukorrhea.

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4한방 산후조리 이용 산모의 특성과 치료결과 보고 -2010년 선행 연구와의 비교 고찰 -

저자 : 노은지 ( Eun-ji Noh ) , 최수지 ( Su-ji Choi ) , 이동녕 ( Dong-nyung Lee ) , 김동일 ( Dong-il Kim )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 57-72 (16 pages)

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Objectives: This study aims to assess the maternal characteristics and changes of body among patients who received Korean medicine postpartum care compared to pre-study.
Methods: From January 1, 2018 to February 28, 2019, we included 31 postpartum patients who had body composition analysis at admission and discharge among 34 patients who received postpartum care in □□ University Hospital. We used SPSS 21.0 for window to test for statistical significance.
Results: The average age, weight, and caesarean section rate increased compared to previous study. The average period of postpartum care has decreased. After postpartum care, abdominal circumference, body weight and Body Mass Index (BMI) was significantly decreased, but not as much as pre-study. The coefficient of determination was derived to predict the effects of postpartum care and calculated as “Abdominal circumference change = 2.745+0.593xadmission period”, “weight change = 0.214+0.345xadmission period” and ”BMI change = 0.198+0.120xadmission period”.
Conclusions: Compared to previous study, as the maternal age increased and admission period decreased, the weight loss after childbirth decreased. It is necessary to provide individual treatment through coefficient of determination.

KCI등재

5임신 중 교통사고의 한의학적 치료에 대한 연구동향 분석

저자 : 김남훈 ( Nam-hoon Kim ) , 황덕상 ( Deok-sang Hwang ) , 이진무 ( Jin-moo Lee ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 73-85 (13 pages)

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Objectives: The purpose of this study was to analyze efficacy and safety of Korean Medicine treatment for traffic accidents during pregnancy.
Methods: We investigated the studies on Korean Medicine treatment for traffic accidents during pregnancy via searching through PUBMED, the Cochrane Library, CNKI, and domestic search engines and a total of 6 studies were selected.
Results: The major complaints of traffic accidents during pregnancy were low back pain, neck pain and gastrointestinal symptoms. And there were vaginal bleeding and pruritus vulvae in the complaints. All of the studies were given acupuncture treatment for symptom relief, and chuna, herbal acupuncture and cupping were administered. Herbal medicine was also performed, and the most prescribed herbal medicine was Antaeeum-gamibang. All cases reported as traffic accidents during pregnancy showed a reduction in symptoms, normal pregnancy maintenance and delivery, and no miscarriage were reported.
Conclusions: Korean Medicine treatment is an effective and safe treatment option for traffic accidents during pregnancy. Further systematic studies are needed to establish the basis for Korean Medicine treatment for traffic accidents during pregnancy.

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6간질성 방광염의 침 치료에 관한 임상 연구 고찰

저자 : 구수정 ( Su-jeong Ku ) , 황덕상 ( Deok-sang Hwang ) , 이진무 ( Jin-moo Lee ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 86-101 (16 pages)

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Objectives: This review is aimed at assessing the efficacy and effectiveness of acupuncture treatment for interstitial cystitis patients through literature research and overview.
Methods: Database searching was conducted to identify relevant randomized controlled trials (RCTs) and clinical studies on the acupuncture treatment for interstitial cystitis patients. Studies were searched from Journal of Korean Obstetrics and Gynecology, KISS, KMBASE, CNKI, Cochrane library, PubMed and Em Base up to April 2019.
Results: Five studies including three RCTs and two clinical studies were finally selected. Three studies showed that acupuncture was effective for interstitial cystitis. One study showed ineffectiveness of acupuncture treatment.
Conclusions: From three studies, acupuncture treatment for interstitial cystitis patients showed symptoms relief and improvement of QoL (Quality of Life). Further strictly designed studies are needed to confirm the efficacy and setup the acupuncture treatment protocol.

KCI등재

7유방암 환자의 이차성 림프부종에 대한 침 치료 임상 연구 고찰

저자 : 박경덕 ( Kyung-dug Park ) , 황수인 ( Su-in Hwang ) , 박장경 ( Jang-kyung Park ) , 윤영진 ( Young-jin Yoon )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 102-115 (14 pages)

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Objectives: The purpose of this study is to confirm the effectiveness and safety of acupuncture for treating breast cancer-related lymphedema (BCRL), thus providing a clinical basis for acupuncture treatment and helping to develop clinical practice guideline through consideration of used meridians and acupoints.
Methods: Clinical studies applying acupuncture on breast cancer-related lymphedema were searched through 7 databases such as The Cochrane Library Central, Embase, Pubmed and CAJ. Interventions and results of the selected clinical studies were analyzed.
Results: 8 Clinical studies were finally included according to inclusion and exclusion criteria. There were 6 randomized controlled studies and 2 single-arm pilot studies. All of those studies were searched in The Cochrane Library Central, Embase, Pubmed and CAJ and written in English and Chinese. Treatment group applied acupuncture as a Korean medicine intervention. Interventions of control group were made with non-treatment, upper limb exercise, and oral administration of capillary stabilizer or diuretics. Outcome measurements varied from paper to paper but every study measured reduction in arm circumference. Among 8 studies, 6 studies reported statistically significant reduction in arm circumference in treatment group and there were no serious adverse effects.
Conclusions: This study suggested that acupuncture has few side effects as well as statistically significant effects on many aspects in treating breast cancer-related lymphedema. However the results should be taken cautiously as more clinical studies are needed.

KCI등재

8가미통경탕(加味通經湯)의 원발성 월경통에 관한 임상적 효과 :후향적 차트 리뷰

저자 : 김하늘 ( Ha-neul Kim ) , 김민지 ( Min-ji Kim ) , 유영재 ( Yeong-jae Yoo ) , 김서영 ( Seo-young Kim ) , 임영우 ( Young-woo Lim ) , 박영배 ( Young-bae Park )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 116-127 (12 pages)

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Objectives: The purpose of this study is to evaluate the effects of Gamitonggyung-tang on Primary Dysmenorrhea.
Methods: We treated 33 cases of primary dysmenorrhea patients with Gamitonggyung-tang for three menstrual cycles. We estimated the effects by Visual Analog Scale (VAS), Menstrual Distress Questionnaire (MDQ) and checked amount of the analgesics taken during menstrual phase.
Results: After treatment, the mean of VAS, MDQ Score and amount of the analgesics taken were decreased.
Conclusions: This case shows that Gamitonggyung-tang is effective in treating primary dysmenorrhea patients.

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9비스테로이드성 소염진통제를 복용하는 원발성 월경곤란증 환자에 대한 하복부 온열찜질기의 효과

저자 : 김형준 ( Hyeong-jun Kim ) , 이동녕 ( Dong-nyung Lee ) , 안하영 ( Ha-young Ahn )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 128-141 (14 pages)

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Objectives: This study was performed to investigate the pain relief effect of lower abdomen warmer on primary dysmenorrhea patients taking nonsteroidal anti-inflammatory drugs and whether the using of warmer can supplement or replace the drugs.
Methods: 30 women with primary dysmenorrhea were assigned to treatment group (n = 15) and control group (n = 15). At 1st visit, the treatment group was provided with a wirless multiuse warmer and trained to use at least three times per menstrual cycle. The control group was not provided with the warmer, and both groups were provided with a menstrual diary and instructed to record their pain intensity and dose of analgesic every menstrual period. Visual Analogue Scale (VAS) were used to assess the intensity of overall pain and the most severe pain during the menstrual period. And the total number of analgesic taken during menstruation and the average number of analgesic taken during a single dose were measured.
Results: There was significant pain relief in the treatment group compared to before baseline, and there was a significant difference from the control group. In addition, there was no significant difference in the frequency of taking analgesic during the menstrual period between the treatment group and the control group, but the dose of analgesic was significantly lower in the treatment group than in the control group.
Conclusions: This clinical trial showed that lower abdomen warmer would helpful in relieving primary dysmenorrhea and could help reduce the use of nonsteroidal anti-inflammatory drugs.

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10부인과 수술 후 한방 조기 회복 치료를 받은 입원 환자에 대한 후향적 분석

저자 : 김혜원 ( Hae-won Kim ) , 유정은 ( Jeong-eun Yoo )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 32권 3호 발행 연도 : 2019 페이지 : pp. 142-161 (20 pages)

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Objectives: The purpose of this study is to report the effect and safety of traditional Korean medicine (TKM) for enhanced recovery after surgery (ERAS) after gynecological surgery.
Methods: The study is conducted by analyzing the medical records of the hospitalized patients in TKM hospital. Eighty-six patients were enrolled who received TKM for ERAS after gynecological surgery from January 2015 to April 2018. We performed statistical analysis by using SPSS ver. 25.0. To prove the effect and safety of TKM for ERAS, we analyzed symptoms and Hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and serum creatinine (Cr) with glomerular filtration rate (GFR). In addition, we checked other adverse reactions that the patients complained to prove the safety of TKM for ERAS.
Results: Among symptoms of pain, there was a statistically significant decrease in abdommal pain lower back pain, and shoulder pain. Other symptoms showed statistically significant improvement in fatigue, abdominal tympanosis, operation-site discomfort, dizziness, urinary discomfort, throat discomfort, constipation, dyspepsia and colporrhagia. Anemia in both ferritin combination treatment group and herbal medicrne only group showed significant improvement. There was no liver damage or renal damage by TKM.
Conclusions: The result has shown that TKM for ERAS after gynecological surgery is effective and safe. The further study of TKM for ERAS with more patients is needed.

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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