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한국운동생리학회(구 한국운동과학회)> 운동과학> MK-801 처치와 지구성 훈련이 심근의 혈관생성 반응에 미치는 영향

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MK-801 처치와 지구성 훈련이 심근의 혈관생성 반응에 미치는 영향

Effect of MK-801 Treatment and Endurance Training on Angiogenic Response in Cardiac Muscle

홍영표 ( Youngpyo Hong ) , 여효성 ( Hyoseong Yeo )
  • : 한국운동생리학회(구 한국운동과학회)
  • : 운동과학 28권2호
  • : 연속간행물
  • : 2019년 05월
  • : 150-158(9pages)

DOI


목차

서 론
연구 방법
연구결과
논 의
결 론
CONFLICT OF INTEREST
REFERENCES

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초록 보기


						
PURPOSE: The purpose of this study was to investigate the effects of regular endurance exercise on the changes of angiogenic biomarkers in myocardial tissues of the schizophrenia-induced rats.
METHODS: Twenty-one SD rats were randomly assigned to CON (n=7), MK (n=7) and MK+ET (n=7) groups. MK and MK+ET groups were treated with MK-801 for 2 weeks before endurance training. MK+ET group ran on a rodent treadmill at 22 m/min for 4 weeks (5 days/week, 30 min/day) after the treatment. Protein expressions of NMDA receptor and angiogenic factors (HIF-1α, VEGF, Flk-1, Ang-1,-2) in myocardial tissue were analyzed by western blot.
RESULTS: Expression of NMDA receptor (p=.004), VEGF (p=.016), Flk-1 (p=.001), Ang-1 (p=.001), Ang-2 (p=.015) in MK group were significantly lower than in CON group. On contrary, MK+ET group showed no significant expression of NMDA receptor, VEGF and Flk-1 compared to CON group (p>.05). Ang-1 (p=.001) and Ang-2 (p=.001) expression of MK+ET group were significantly lower than those of CON group, whereas Ang-1 expression in MK+ET (p=.024) group was higher than that of MK group. In addition, Ang-2: Ang-1 ratio in MK (p=.001) group was significantly higher than in CON group, however there was no difference between CON and MK+ET group (p>.05).
CONCLUSIONS: These results suggest that the reduction of NMDA receptors by MK-801 may negatively affect the angiogenic responses in myocardial tissue and that regular endurance exercise may have the effect of improving them.

UCI(KEPA)

I410-ECN-0102-2019-600-001698216

간행물정보

  • : 예체능분야  > 체육학
  • : KCI등재
  • :
  • : 계간
  • : 1226-1726
  • : 2384-0544
  • : 학술지
  • : 연속간행물
  • : 1996-2020
  • : 974


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1'운동과학'이 가야할 길

저자 : 김창선

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 99-101 (3 pages)

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2대사 및 심혈관계 질환에 대한 아디포넥틴 수용체 활성제, 아디포론의 잠재적 역할

저자 : 조은희 ( Eunhee Cho ) , 이세원 ( Sewon Lee )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 102-109 (8 pages)

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PURPOSE: Adiponectin has beneficial effects on metabolic and cardiovascular disease. Adiponectin receptor agonist, AdipoRon was discovered in 2013 and it may play an important role in preventing and ameliorating cardiometabolic disease. However, the physiological function and signal transduction of AdipoRon are still under way, and the potential role of AdipoRon in metabolic and cardiovascular diseases has not been clearly elucidated. The purpose of this review is to provide basic knowledge for the potential role of AdipoRon in cardiometabolic disease.
METHODS: In this review, we summarized the previous studies (published between 2013 and 2019) investigating the effect of AdipoRon on metabolic and cardiovascular disease.
RESULTS: The previous evidences have shown that AdipoRon treatment exerted its pleiotropic actions on metabolism related tissue and organs including adipose tissue, skeletal and cardiac muscles, liver, kidney, and vascular beds. Activation of adiponectin receptors may be effective for the treatment of metabolic and cardiovascular diseases due in part to activation of AMPK and PPARα signaling pathway as adiponectin does.
CONCLUSIONS: In conclusion, AdipoRon can be a novel therapeutic agent for the cardiometabolic disease. However, all of previous studies were conducted using experimental animal models and it is needed to investigate the role of AdipoRon in metabolic and cardiovascular disease in human.

3척수손상인의 일반적 특성에 따른 체력적 특징과 운동 전략

저자 : 이근호 ( Kun-ho Lee ) , 홍상민 ( Sang-min Hong ) , 신윤아 ( Yun-a Shin )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 110-121 (12 pages)

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PURPOSE: Spinal cord injuries cause a decrease in overall body function after spinal cord injury. The physical fitness of the spinal cord injured person varies greatly depending on the level of injury, physical activity, and the use of a wheelchair. Therefore, exercise prescription programs that take into account the type of disability of the spinal cord injuries will help improve physical fitness. The purpose of this study was to identify the physical characteristics of spinal cord injured people by examining previous studies and to suggest strategies for applying effective exercise programs.
METHODS: This study was conducted to investigate previous studies and to present the physical characteristics of spinal cord injuries according to spinal cord injury level, physical activity level and wheelchair use, and to determine the appropriate exercise test method and effective exercise prescription strategy.
RESULTS: This study suggested the exercise test method considering the physical characteristics of the spinal cord injured people and the NMES exercise program for the cardiorespiratory capacity enhancement exercise program and the NMES exercise program for the prevention of the lower extremity muscle activity.
CONCLUSIONS: The application of a customized exercise prescription program for spinal cord injuries would have a positive effect on the prevention of secondary complications due to spinal cord injury and improvement of the quality of life of people with spinal cord injury. Based on the results of this study, we expect that the scientific exercise prescription program will be applied to people with spinal cord injuries.

4크로스핏 트레이닝이 여자 아동의 체력, 혈중지질 및 골대사 지표에 미치는 영향

저자 : 유동훈 , 허유섭

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 122-130 (9 pages)

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PURPOSE: The purpose of this study was to investigate the effects of crossFit training on physical fitness, blood lipids and bone metabolism index of prepubescent girls.
METHODS: Eighteen elementary school girls were assigned to either crossFit training group (CTG: n=9, Height: 148.08±5.80 cm, Weight: 58.26±3.29 kg, Age: 11.44±0.73 year) or control group (CON: n=9, Height: 147.49±5.41 cm, Weight: 56.83±3.72 kg, Age: 11.22±0.83 year). crossFit training program consisted of workout of the day (WOD) with 3-4 items for 10 weeks (3 day per week).
RESULTS: The results were as follows: 1) The hand grip, back strength, sit-up, sargent jump, eyes-closed one-leg standing and trunk flexion were increased significantly in the CTG. 2) The TC, TG, LDL-C were decreased significantly, and the HDL-C was increased significantly in the CTG. 3) The osteocalcin was increased significantly in the CTG, but there were no significant difference in the alkaline phosphatase and calcitonin.
CONCLUSIONS: CrossFit training was effective for physical fitness and blood lipids but there was no significant difference in bone metabolism index. Long-term exercise may be effective for positive changes in bone metabolism index and further study on crossFit training consisting of different exercise intensity, period, and frequency should be performed on prepubescent girls.

5모래지면 운동프로그램이 여성노인의 균형능력, 근활성도 및 염증인자에 미치는 효과

저자 : 이성수 ( Sung-soo Lee ) , 소용석 ( Yong-seok So )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 131-140 (10 pages)

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PURPOSE: The primary objective of this study was to investigate the effect of sand surface exercise compare with general surface exercise on balance capability, extremity muscle activity, and inflammatory markers in older women.
METHODS: A total of 40 subjects aged over 65 years were enrolled for this study. They were assigned into two groups (20 subjects in each group): 1) exercise on sand (SG); and 2) exercises on general ground (HG).
RESULTS: There was no interaction effect between group and time on body composition and blood pressure. There were significant difference in overall, anterior/posterior, medial/lateral between the SG and HG. And changes in proprioceptive sensation were significantly different between the two groups. Knee extension was also significantly higher in the HG than in the sand group. There were significant difference in the tibialis anterior, the gastrocnemius, and biceps femoris between the SG and HG. There were significant increases in respective muscle activities after exercises in SG. After the exercise program, there was a significant difference between times in C-reactive protein (CRP). There were significant difference in rheumatoid arthritis factor (RA factor) factor between the SG and HG. Also, SG resulted in a greater reduction in RA factor than the HG.
CONCLUSIONS: Our results suggest that sand exercise program can produce benefits with regard to balancing capacity functional improvement, reduction of inflammatory markers, and prevention of proprioceptive sensation in the older women, thus contributing to a better quality of life.

6Effect of FIFA 11+ Training Program on Soccer-Specific Physical Performance and Functional Movement in Collegiate Male Soccer Players: A Randomized Controlled Trial

저자 : Juyoung Hwang , Jooyoung Kim

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 141-149 (9 pages)

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PURPOSE: This study aimed to investigate the effects of the FIFA 11+ training program on soccer-specific physical performance and functional movement of collegiate male soccer players.
METHODS: Twenty healthy male soccer players (age: 20.0±0.7 years, height: 174.2±4.3 cm, weight: 67.3±7.0 kg) participated in this study and were randomly divided into the 11+ training group (n=10) and control group (n=10). The FIFA 11+ training program was incorporated five times a week for 12 weeks and each session took about 20-25 minutes. The control group performed a normal warm-up. Participants' soccer-specific physical performance (10-m and 30-m sprint test, coordination test, arrowhead agility test, and Yo-Yo intermittent recovery test level 1 (Yo-Yo IR test level 1) and functional movement (deep squat, hurdle step, in-line lunge, shoulder mobility, straight-leg raise, trunk stability push-up, and rotary stability) were measured.
RESULTS: The results showed that the FIFA 11+ training program group showed a significant improvement in the 30-m sprint (p=.027), coordination test (p=.021), and arrowhead agility test (right: p=.009, left: p=.004), but not in the 10-m sprint and Yo-Yo IR test level 1, compared to the control group. Regarding functional movement, the FIFA 11+ training program group showed significantly better deep squat (p=.035), hurdle step (p=.005), rotary stability (p=.005), and total FMS scores (p=.001) than the control group.
CONCLUSIONS: We concluded that a 12-week FIFA 11+ training program had positive effects on soccer-specific physical performance and functional movement of collegiate male soccer players.

7MK-801 처치와 지구성 훈련이 심근의 혈관생성 반응에 미치는 영향

저자 : 홍영표 ( Youngpyo Hong ) , 여효성 ( Hyoseong Yeo )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 150-158 (9 pages)

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PURPOSE: The purpose of this study was to investigate the effects of regular endurance exercise on the changes of angiogenic biomarkers in myocardial tissues of the schizophrenia-induced rats.
METHODS: Twenty-one SD rats were randomly assigned to CON (n=7), MK (n=7) and MK+ET (n=7) groups. MK and MK+ET groups were treated with MK-801 for 2 weeks before endurance training. MK+ET group ran on a rodent treadmill at 22 m/min for 4 weeks (5 days/week, 30 min/day) after the treatment. Protein expressions of NMDA receptor and angiogenic factors (HIF-1α, VEGF, Flk-1, Ang-1,-2) in myocardial tissue were analyzed by western blot.
RESULTS: Expression of NMDA receptor (p=.004), VEGF (p=.016), Flk-1 (p=.001), Ang-1 (p=.001), Ang-2 (p=.015) in MK group were significantly lower than in CON group. On contrary, MK+ET group showed no significant expression of NMDA receptor, VEGF and Flk-1 compared to CON group (p>.05). Ang-1 (p=.001) and Ang-2 (p=.001) expression of MK+ET group were significantly lower than those of CON group, whereas Ang-1 expression in MK+ET (p=.024) group was higher than that of MK group. In addition, Ang-2: Ang-1 ratio in MK (p=.001) group was significantly higher than in CON group, however there was no difference between CON and MK+ET group (p>.05).
CONCLUSIONS: These results suggest that the reduction of NMDA receptors by MK-801 may negatively affect the angiogenic responses in myocardial tissue and that regular endurance exercise may have the effect of improving them.

8저항훈련은 랫 골격근에서 finasteride에 의해 유도된 단백질 항상성 교란을 개선시킨다

저자 : 오성희 ( Sung-hee Oh ) , 이동원 ( Dong-won Lee ) , 이유현 ( Yoo-hyun Lee ) , 주정선 ( Jeong-sun Ju )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 159-167 (9 pages)

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PURPOSE: Finasteride is a competitive inhibitor of 5-alpha reductase type 2 enzyme that is commonly used to treat benign prostatic hyperplasia and male pattern hair loss. It is not clear about the synergistic effects of finasteride and resistance training on protein homeostasis in androgen-target tissue such as skeletal muscle. Thus, the purpose of this study was to investigate the effects of 8-week finasteride and resistance exercise training on protein synthesis and autophagic degradation in rat skeletal muscle.
METHODS: Forty-eight male wild-type Sprague Dawley rats (8weeks old) were randomly assigned into 4 groups: (1) sedentary control, (2) finasteride, (3) exercise, and (4) exercise plus finasteride. Rats of the finasteride group received finasteride, dissolved in corn oil (10 mg/kg) by oral gavage. Rats of the exercise group climbed a 1-m ladder inclined at 85° every 3 days for 8 weeks as a means of resistance exercise. They climbed the ladder 8 times with the load of 50%, 75%, 90%, and 100% of its body weight. Rates of the exercise plus finasteride group were given both interventions. We assessed autophagy flux, protein synthesis (mTOR signaling and translation rate using the SUnSET assay), and muscular functions before and after 8-weeks of intervention, and performed one-way ANOVA to determine pre-post differences in each group.
RESULTS: The finasteride treatment significantly reduced protein synthesis while activating autophagic degradation in skeletal muscle of rats. The exercise training increased both protein synthesis and autophagic degradation. The combined treatments decreased both protein synthesis and autophagy flux in the skeletal muscle (p<0.05).
CONCLUSIONS: Eight weeks of finasteride treatment appears to disturb the protein homeostasis, which is viewed as a balance of protein synthesis and degradation through the reduction in protein synthesis and activation in autophagic degradation simultaneously in skeletal muscle. Resistance exercise appears to alleviate the disruption of protein homeostasis induced by finasteride treatment.

9청소년 대상의 20 m 왕복오래달리기 검사를 통한 최대산소섭취량 추정식 개발

저자 : 이온 ( On Lee ) , 정진욱 ( Jin-wook Chung )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 168-174 (7 pages)

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PURPOSE: The purpose of this study was to investigate the validity of the 20 m PACER and to develop accurate and practical prediction models of maximal oxygen consumption using 20 m PACER.
METHODS: In total 407 (male 207, female 200) in middle and high school students participated in this study. Maximal oxygen uptake was measured using the maximal-graded exercise treadmill test. Sex, age, and anthropometrics variable were measured as potential predictors. Each test was conducted within a week interval, ensuring sufficient rest. Correlation analysis was performed to investigate the validity of 20 m PACER. Regression analysis was performed to develop the maximum oxygen uptake prediction equation using the 20 m PACER. The accuracy of prediction models was evaluated using R2, standard error of estimate (SEE), mean difference (MD), and limit of agreement (LoA%) against a criterion-measured of maximal oxygen uptake.
RESULTS: 20 m PACER was respectively .675 (.001) in male students .585 (.001) in female students showed reasonable validity. The equation of the following was developed (R2=0.77; SEE=3.58): VO2max=53.550+0.169 (20 m PACER)-0.333 (%body fat)+2.276 (sex)-0.080 (height). Gender has a value of 0 for men and 1 for women.
CONCLUSIONS: The prediction models included 4 variables as significant predictors of maximal oxygen uptake and had acceptable accuracy in a large sample of South Korean adolescent. Therefore, developed equation in this study is recommended for better estimation of cardiopulmonary fitness of middle and high school students.

10한국 국가대표 남자 복싱선수들의 코어 근력에 대한 연구: 무산소성 파워와 최대근력의 상관관계

저자 : 윤동현 ( Dong-hyun Yoon ) , 김광준 ( Kwang-jun Kim )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 28권 2호 발행 연도 : 2019 페이지 : pp. 175-181 (7 pages)

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PURPOSE: We examined associations between core strength and anaerobic Power and maximal strength in Korean national amateur male boxers.
METHODS: Cross-sectional associations between core strength were examined in 92 Amateur elite Boxers (mean age: 22.2± 2.60 years). Anaerobic Power and Maximal Strength were obtained. Main outcome measures included Wingate anaerobic test and arm ergometer test and Isokinetic Knee strength and 1RM.
RESULTS: Isokinetic trunk flexion and extension were associated with Anaerobic power (upper and lower Average power and peak power). In addition, trunk strength of flexion and extension were significantly associated with of maximal strength (Knee extension and flexion and 1RM).
CONCLUSIONS: Isokinetic trunk strength revealed an association between Anaerobic Power and Maximal Strength. Future research addressing the contributions of the core strength could be conducted with the proper training program development in mind. Additionally, studies about the years of boxing training necessary to achieve an international competitive level and the common boxing-specific training used by Olympic-level boxers are needed.

12
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대한무도학회지
22권 2호 ~ 22권 2호

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국기원태권도연구
11권 2호 ~ 11권 2호

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International Journal of Applied sports sciences (IJASS)
32권 1호 ~ 32권 1호

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체육과학연구
31권 2호 ~ 31권 2호

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한국운동역학회지
30권 2호 ~ 30권 2호

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한국특수체육학회지
28권 2호 ~ 28권 2호

International Journal of Human Movement Science
14권 1호 ~ 14권 1호

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스포츠사이언스
38권 1호 ~ 38권 1호

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한국리듬운동학회지
13권 1호 ~ 13권 1호

Asia Pacific Journal of Applied Sport Sciences
1권 1호 ~ 1권 1호

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29권 2호 ~ 29권 2호

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한국체육학회지
59권 3호 ~ 59권 3호

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23권 2호 ~ 23권 2호

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151권 0호 ~ 151권 0호

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한국체육정책학회지
53권 0호 ~ 53권 0호

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대한무도학회지
22권 1호 ~ 22권 1호

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Asian Journal of Physical Education of Sport Science(AJPESS)
8권 1호 ~ 8권 1호

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국기원태권도연구
11권 1호 ~ 11권 1호
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