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한국운동생리학회(구 한국운동과학회)> 운동과학> 골격근 위축에 대한 운동 메커니즘: 기전적 분석

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골격근 위축에 대한 운동 메커니즘: 기전적 분석

Role of Exercise in Skeletal Muscle Atrophy: A Mechanistic Investigation

서대윤 ( Dae Yun Seo ) , 배준현 ( Jun Hyun Bae ) , 방현석 ( Hyun Seok Bang ) , 곽이섭 ( Yi Sub Kwak )
  • : 한국운동생리학회(구 한국운동과학회)
  • : 운동과학 29권3호
  • : 연속간행물
  • : 2020년 08월
  • : 202-207(6pages)

DOI


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서론
결론
CONFLICT OF INTEREST
ORCID
AUTHOR CONTRIBUTIONS
REFERENCES

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PURPOSE: Skeletal muscle atrophy induces overall health problems and many related diseases in older adults. In particular, sarcopenia is related to lowered quality of life, decreased physical activity, high levels of morbidity and mortality owing to chronic diseases, and even falling. Despite the many clinical studies on skeletal muscle atrophy, a little study had been about the exact mechanism of skeletal muscle atrophy at the molecular level. In 2017, A disease code (ICD-10-CM) for skeletal muscle atrophy related to sarcopenia was announced to attempt a clinical approach in the United States. According to these approaches, non-invasive clinical treatment is the most effective method for treating skeletal muscle atrophy. The purpose of this study was to analyze the molecular mechanisms of muscular exercise and related skeletal muscle atrophy factors.
METHODS: This systemic review focused on skeletal muscle atrophy and muscular exercise. The keywords were used on “MeSH: muscle atrophy OR skeletal muscle atrophy OR muscle OR atrophy AND physical exercise OR exercise OR exercise training” for English and Korean. This paper searched PubMED, OVIDMEDLINE, and EMBASE for literature consideration.
RESULTS: Skeletal muscle atrophy was related to a complex molecular network, and exercise affects IGF-1/Akt/mTOR signaling. The related skeletal muscle atrophy factors were evaluated as MurF1, MAFbx, IGF-1, and NFkB. We proposed new related factors such as ATF 4, Gadd45a, and p21; however, the results related to exercise were not shown in recent studies.
CONLCUSIONS: In conclusion, we identified skeletal muscle atrophy factors at the molecular level of muscle physiology, and these new factors may become an interesting field of study in clinical human trial and animal studies.

UCI(KEPA)

간행물정보

  • : 예체능분야  > 체육학
  • : KCI등재
  • :
  • : 계간
  • : 1226-1726
  • : 2384-0544
  • : 학술지
  • : 연속간행물
  • : 1996-2020
  • : 990


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1운동과학의 뉴노멀

저자 : 백성수 ( Seung-soo Baek )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 201-201 (1 pages)

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2골격근 위축에 대한 운동 메커니즘: 기전적 분석

저자 : 서대윤 ( Dae Yun Seo ) , 배준현 ( Jun Hyun Bae ) , 방현석 ( Hyun Seok Bang ) , 곽이섭 ( Yi Sub Kwak )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 202-207 (6 pages)

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PURPOSE: Skeletal muscle atrophy induces overall health problems and many related diseases in older adults. In particular, sarcopenia is related to lowered quality of life, decreased physical activity, high levels of morbidity and mortality owing to chronic diseases, and even falling. Despite the many clinical studies on skeletal muscle atrophy, a little study had been about the exact mechanism of skeletal muscle atrophy at the molecular level. In 2017, A disease code (ICD-10-CM) for skeletal muscle atrophy related to sarcopenia was announced to attempt a clinical approach in the United States. According to these approaches, non-invasive clinical treatment is the most effective method for treating skeletal muscle atrophy. The purpose of this study was to analyze the molecular mechanisms of muscular exercise and related skeletal muscle atrophy factors.
METHODS: This systemic review focused on skeletal muscle atrophy and muscular exercise. The keywords were used on “MeSH: muscle atrophy OR skeletal muscle atrophy OR muscle OR atrophy AND physical exercise OR exercise OR exercise training” for English and Korean. This paper searched PubMED, OVIDMEDLINE, and EMBASE for literature consideration.
RESULTS: Skeletal muscle atrophy was related to a complex molecular network, and exercise affects IGF-1/Akt/mTOR signaling. The related skeletal muscle atrophy factors were evaluated as MurF1, MAFbx, IGF-1, and NFkB. We proposed new related factors such as ATF 4, Gadd45a, and p21; however, the results related to exercise were not shown in recent studies.
CONLCUSIONS: In conclusion, we identified skeletal muscle atrophy factors at the molecular level of muscle physiology, and these new factors may become an interesting field of study in clinical human trial and animal studies.

3Role of Exercise-induced Adiponectin Activation on Obese and Diabetic Individuals

저자 : Kangil Lim , Kijeong Kim

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 208-213 (6 pages)

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PURPOSE: The physiological role of adipocytokines on obesity, diabetes, and insulin resistance is not clearly understood yet. Furthermore, the mechanism of exercise-induced changes in plasma adiponectin in obesity and diabetes is not known well. The aim of this review is to describe the role of exercise on the adiponectin production in adipose tissue of the obesity and diabetes.
METHODS: This study reviews 46 previous studies focusing on the effect of exercise on adiponectin in obese and diabetic individuals.
RESULTS: Increasing adiponectin levels after long-term exercise training in obese and diabetic individuals have inconsistent support in the scientific literature. However, the present review summarized evidence that supports for exercise training as a viable strategy to increase adiponectin in obese and diabetic individuals.
CONCLUSIONS: Despite the importance of regular physical activity for the prevention of obesity and diabetes outlined in numerous guidelines and recommendations, previous studies showed inconsistent results regarding the effect of physical activity among obese and diabetic individuals. This review suggested that exercise training induces the augmentation of the anti-inflammatory cytokine adiponectin and in turn, it provides long-term health outcomes for obese and diabetic individuals.

4회복 처치 방법에 따른 주짓수 모방 시합 중과 후의 신체수행력 및 염증반응

저자 : 박종현 ( Jong-hyun Park ) , 이상현 ( Sang-hyun Lee ) , 김수진 ( Su-jin Kim ) , 송정란 ( Jung-ran Song ) , 곽효범 ( Hyo-bum Kwak ) , 강주희 ( Ju-hee Kan ) , 박동호 ( Dong-ho Park )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 214-224 (11 pages)

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PURPOSE: The purpose of this study was to induce sufficient fatigue through the Jiu-Jitsu game imitation exhaustion treatment that reflects the characteristics of Jiu-Jitsu competition, and then fatigue-related indicators according to the self-healing treatment method performed during the break between each treatment and to examine the effect on Jiu-Jitsu exercise performance.
METHODS: Eight Jiu-Jitsu athletes (28.3±3.62 years, 24.6±2.5 kg/m2, 14.6±4.6% fat) participated in the study, and their exercise performance, RPE, lactate, CK, and CRP were measured after inducing exhaustion using the Jiu-Jitsu Fight Gone Bad (JFGB; 4 rounds×6 minutes JFGB, 12 minutes of recovery between rounds) test. These variables analyzed using two-way ANOVA with bonferroni's correction.
RESULTS: All the exercise performance, lactate level, and RPE showed only the difference over time according to JFGB treatment, and there was no significant difference according to recovery methods (passive recovery; PR, active recovery; AR, cryotherapy; CTR, oxygen inhalation; OIR). On the other hand, in the case of CRP, there was no significant difference in interaction effect, group, and time main effects. CK showed a significant difference only before and after JFGB treatment, but similarly, there was no difference according to recovery methods.
CONCLUSIONS: Regardless of the recovery method, all variables showed a significant difference only over time according to the JFGB test, and the AR, CTR, and OIR methods were similar to the PR. However, it was observed that in the case of CK, immediately after the JFGB test, it increased significantly regardless of recovery measures.

5Ankle Joint Cooling did not but Knee Joint Cooling altered the Quadriceps and Gastrocnemius Neuromuscular Activation During a Single-leg Drop Jump

저자 : Jihong Park , Kyeongtak Song , Sae Yong Lee , Hohyung Ryu

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 225-232 (8 pages)

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PURPOSE: We examined the immediate effect on ankle or knee joint cooling on the lower-extremity activation during a single-leg drop jump.
METHODS: Twenty healthy adults randomly completed three data collection sessions (a 20-minute ankle or knee joint cooling, or control). Two wireless surface electromyography (EMG, 2,000 Hz) electrodes were attached over the vastus medialis (VM) and the medial gastrocnemius (MG) on their right limb. Subjects were asked to drop down from a wooden box (a 30-cm height) on their right foot onto the force platform (2,000 Hz) and then performed an immediate jump as high as they could. Whole EMG signals (normalised by the mean EMG value recorded during a reference position) within the preactivation (100-ms prior to contact) and the ground contact (on the force platform) during the drop jump task were analysed using functional linear models (p=.05, Cohen's d effect size: ES).
RESULTS: After knee joint cooling, (1) the VM activation was decreased during the ground contact (6 to 14%, 30 to 45%, 60 to 90% for ES of 0.50, 0.47, and 0.61, respectively) and (2) the MG activation was increased during the preactivation (84- to 29-ms prior to initial contact, ES=1.30) and the ground contact (59 to 100%, ES=1.40). No changes were observed under the condition of ankle joint cooling or control.
CONCLUSIONS: A 20-minute unilateral knee joint cooling may result in an ipsilateral quadriceps inhibition during a drop jump task. The gastrocnemius appears to increase activation as a compensatory strategy responding to the quadriceps inhibition. The altered neuromuscular activations do not seem to put an individual at risk of injury, resulting from compressive forces in the sagittal plane.

6복합운동이 전단계노쇠 고령 여성의 노쇠지표, 경동맥 경직도 및 탄성도에 미치는 영향

저자 : 장윤정 ( Yung-jung Jang ) , 김태규 ( Tea-kyu Kim ) , 박진기 ( Jin-kee Park )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 233-241 (9 pages)

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PURPOSE: We studied the effects of combined exercise (CE) on frailty index, physical function, carotid artery (CA) distensibility, and beta-stiffness in pre-frailty older women.
METHODS: A total of 27 pre-frailty older women (aged 70.6±4.0 years), who were divided into a control group (n=13) and a supervised CE group (n=14). The 12-week CE program (resistance and aerobic exercise) consisted of sessions 50 minutes in length 3 days per week under the supervision of an exercise specialist. Frailty index, blood pressure, physical function, and CA function were assessed.
RESULTS: Frailty status showed a significantly (p=.001) group×time interaction. Also, physical activity (p=.019), walking speed (p=.049), and right grip strength (p=.040) showed a significantly group×time interaction. In the CE group, physical activity, walking speed, and right grip strength were significantly (p=.001, p<.001, p<.001) increased, and frailty state was significantly (p<.001) decreased 12-week. Left CA distensibility (p=.032), and beta-stiffness (p=.033) showed a significantly group×time interaction. In the CE group, CA distensibility was significantly (p<.05) increased, and CA beta-stiffness was significantly (p<.01) decreased after 12-week.
CONCLUSIONS: In pre-frail older adult women, CE effectively improves frailty index, CA stiffness, and distensibility.

7Changes of Motor Function according to Attention Differences in Stroke Patients: A Randomized Controlled Trial, Pilot Study

저자 : Sun-young Ha , Yun-hee Sung

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 242-247 (6 pages)

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PURPOSE: The purpose of this study was to investigate the changes of electroencephalography (EEG) activity on balance and gait while physiotherapy in stroke patients.
METHODS: General physiotherapy was applied to 18 stroke patients for 30 minutes per session, 5 times a week, for a total 4 weeks. EEG measured for one week while intervention. Based on the attention score, group was classified into high and low attention groups. We used functional reaching test to measure dynamic balance and GAITRite to measure spatiotemporal variables during gait.
RESULTS: In the high attention group, the sensorimotor rhythm wave was high and the dynamic balance was significantly increased (p<.05). There were significant differences in stance time, single support time, and double support time among temporal variables (p<.05). There were significant differences in step length, stride length, swing % of cycle, stance % of cycle, single support % of cycle, and double support % of cycle among the spatial gait variables (p<.05).
CONCLUSIONS: The high attention during physiotherapy helps improvement of balance and gait ability in stroke patients, therefore, it may be considered in intervention.

8비만유도 노화 흰쥐의 복합 운동이 대동맥, 골격근 및 심근의 HSP70 및 SOD1 발현에 미치는 영향

저자 : 안나영 ( Nayoung Ahn )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 248-255 (8 pages)

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PURPOSE: Exercise improve myocardial cell protection and vascular function through cell repair and suppression of oxidative stress in cardiovascular diseases caused by aging. This study aimed to investigate the effect of combine exercise on HSP70 and SOD1 protein expression of aorta, skeletal muscle and myocardium in high fat diet induced obese aging rats.
METHODS: Male 50-week-old Sprague Dawley rats (n=40) were divided into normal diet (ND, n=10), normal diet+exercise (NDEx, n=10), high fat diet (HFD, n=10), and high fat diet+exercise (HFDEx, n=10) groups. After six weeks on a high fat diet to induce obesity, a 12-week combine exercise program was implemented, which combine exercise (treadmill running+ladder climbing) three times a week for 45 minutes per session.
RESULTS: Body weight was significantly decreased after 12 weeks combine exercise program compared to the ND group (p<.05) and HFDEx group compared to the HFD group (p<.05), respectively. After completing the 12-week exercise program, heat shock protein 70 (HSP70) and superoxide dismutase 1 (SOD1) expressions were significantly (p<.05) higher in the NDEx group compared to the ND group in the myocardium. Also, SOD1 protein expression was significantly (p<.05) higher in the NDEx group compared to the ND group and HFDEx group compared to the HFD group in the skeletal muscle.
CONCLUSIONS: : In conclusion, combine exercise intervention of high fat diet-induced obesity resulted in decreased cell repair protein and antioxidant enzyme protein in the myocardium. Therefore, it is thought that combine exercise intervention for obese induced rats improved the cell repair protein and antioxidant enzyme activity of the myocardium.

912주간 복합운동이 노인 여성의 노인체력, 신체구성 및 백혈구 텔로미어 길이에 미치는 영향

저자 : 신윤철 ( Yun-cheol Shin ) , 장용철 ( Yongchul Jang ) , 조준용 ( Joon-yong Cho )

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 256-263 (8 pages)

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PURPOSE: This study is to investigate the effects of combined exercise on body composition, physical fitness and leukocyte telomere length in elderly women.
METHODS: Twenty-six elderly women were randomly divided into two group: combined exercise group (EXE, n=14) and control group (CON, n=12). EXE group performed combined exercise for 60 mintues per day, 2days/week for 12 weeks.
RESULTS: There was significant interaction between groups and time points in body composition (e.g., skeletal muscle mass, visceral fat area, and Inbody score). EXE group was no significant changes in skeletal muscle mass, visceral fat area and Inbody score, but the CON group showed significant decrease in skeletal muscle mass and Inbody score. Furthermore, increased in visceral fat area. Among the measurement variable of physical fitness, there was significant interaction between group and time in 6 minutes walking test, chair sit test, and knee flexion muscle endurance. In EXE group, 6 minutes walking test and chair test was significantly increased, and there were no significant differences in knee flexion muscle endurance, whereas CON group, the 6 minutes walking test and knee flexion muscle endurance significantly decreased, and there was no significant difference in chair test. In addition, there was significant interaction between groups and time points in leukocyte telomere length. EXE group was no significant changes, but CON group significantly decreased.
CONCLUSIONS: Our study suggest that combined exercise-induced improvement of body composition and physical fitness may have had a positive effect on leukocyte telomere length in elderly women.

10Effects of Acute Alcohol Consumption on Cycling Anaerobic Exercise Performance: A Randomized Crossover Study

저자 : Ting-heng Chou , Chansol Hurr

발행기관 : 한국운동생리학회(구 한국운동과학회) 간행물 : 운동과학 29권 3호 발행 연도 : 2020 페이지 : pp. 264-271 (8 pages)

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PURPOSE: Some athletes consume alcohol prior to training and sports events, possibly because they believe that alcohol may aid in reducing pain and anxiety, increasing confidence, and promoting aggressiveness. While previous studies have shown that alcohol consumption acutely impairs endurance exercise performance, its effects on anaerobic exercise performance have not been well established. Therefore, this study investigated the effect of a small dose of alcohol on anaerobic exercise performance.
METHODS: In a randomized crossover design, nine healthy and recreationally active males (n=6) and females (n=3) participated in the study. Subjects consumed 0.7 g of alcohol per kg of lean body mass or a calorie/volume-matched sucrose beverage. Reaction time tests were performed before and 25 minutes after beverage consumption. Following the second reaction time test, subjects performed the 20-second Wingate anaerobic test (WAnT).
RESULTS: Compared to the sucrose drink, alcohol showed no significant effects on peak power (p=.903), average power (p=.970), percentage power drop during WAnT (p=.593), or total energy produced during WAnT (p=.923). Moreover, alcohol did not affect the time course of power output during a 20s WAnT (p=.999 for all time points). In addition, reaction time was not significantly different when comparing alcoholic with sucrose drinks at different timepoint (Before; p=.999, After; p=.364).
CONCLUSIONS: Although some athletes consume alcohol prior to engaging in sports events, assuming that it may improve anaerobic exercise performance, the results of the present study show that acute consumption of alcohol does not have effects on anaerobic exercise performance when compared to the control beverage.

12
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28권 3호 ~ 28권 3호

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8권 3호 ~ 8권 3호

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국기원태권도연구
11권 3호 ~ 11권 3호

Asia Pacific Journal of Applied Sport Sciences
1권 2호 ~ 1권 2호

스포츠과학
152권 0호 ~ 152권 0호

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